达格列净联合胰岛素治疗2型糖尿病的临床观察

Clinical observation of dapagliflozin and insulin in type 2 diabetes mellitus

目的观察达格列净联合胰岛素治疗2型糖尿病的疗效。方法 60例2型糖尿病患者随机采用胰岛素联合复合维生素(对照组,30例)、达格列净联合胰岛素(达格列净组,30例)治疗24周,比较治疗前后体质量指数(BMI)、血压、血糖、糖化血红蛋白、血脂变化。结果达格列净组治疗后血压、血糖、糖化血红蛋白、血脂、血糖达标时间、胰岛素每日剂量均低于对照组(P<0.01),而两组不良反应差异无统计学意义(P>0.05)。结论达格列净联合胰岛素治疗2型糖尿病疗效明显优于单用胰岛素治疗。

Objective To observe the efficacy of dapagliflozin and insulin in type 2 diabetes mellitus(T2DM).Methods Sixty patients with T2DM were randomly treated with insulin plus multivitamins(control group,n=30)and dapagliflozin plus insulin(treatment group,n=30)for 24 weeks.Body mass index(BMI),blood pressure,and serum levels of glucose,glycosylated hemoglobin and lipid were compared before and after therapy.Results Compared with control group,blood pressure,serum levels of glucose,glycosylated hemoglobin and lipid,glycemic controlling time,and daily insulin dose were remarkably reduced after therapy in treatment group(P<0.01).The adverse effects were comparable between two groups(P>0.05).Conclusion Combined use of dapagliflozin and insulin is superior to single application of insulin for treating T2DM.