耳后注射甲强龙治疗突发性聋34例临床观察

Clinical observation of postauricular methylprednisolone injection in the treatment of sudden hearing loss: 34 cases

目的观察耳后注射甲强龙治疗突发性聋的疗效。方法 70例突发性聋患者随机分为耳后注射组与对照组,耳后注射组给予甲强龙耳后沟中点注射,每隔2天1次,连续3次;对照组给予甲强龙连续3 d静滴,若有效再给予2d后停药,若无效则停用。观察及对比两组入组当天及治疗后1、2、4周的纯音测听结果及疗效。结果耳后注射组治疗后1、2周的纯音测听结果及1周的疗效优于对照组(P<0.01或<0.05);两组治疗后4周的纯音测听结果及2、4周的疗效差异均无统计学意义(P>0.05)。结论耳后注射甲强龙治疗突发性聋可在较短时间内取得更好的听力改善,但最终治疗有效率与全身静脉给药无明显差别。

Objective To assess the efficacy of postauricular injection of methylprednisolone in the treatment of sudden hearing loss.Methods Seventy cases of sudden hearing loss were randomly divided into Treatment Group(34 cases)and Control Group(36 cases).The Treatment Group received postauricular injection of methylprednisolone for once every 2 days and for a total of three times;the Control Group received the intravenous infusion of methylprednisolone for three consecutive days,and for additional 2d if effective,or the drug was discontinued.The pure tone test results and efficacy on the day of enrollment and in the 1st,2nd and 4th week after the treatment were observed and compared between the two groups.Results In terms of the pure tone test results in the 1st week and 2nd week after treatment and the efficacy of the 1st week,the Treatment Group was superior to the Control Group(P<0.01 or<0.05);but there was no statistical difference between the two groups in terms of the pure tone test results in the 4th week after treatment and the efficacy of the 2nd and 4th week(P>0.05).Conclusion Postauricular methylprednisolone injection is an effective way to achieve a better hearing improvement within a short time,but shows no significant difference in terms of the final effective rate and systematic intravenous administration.