两种辅助生殖技术助孕胎儿畸形的影响因素分析

Influence factors of fetal malformation assisted by two kinds of assisted reproductive technology

目的分析两种不同辅助生殖技术方式胎儿畸形的影响因素。方法回顾性分析广东医科大学附属医院生殖医学中心接受体外受精(IVF)或卵胞质内单精子注射(ICSI)的产妇及其子代的临床资料,其中IVF 530例,ICSI 183例。分析影响胎儿畸形的因素。结果 ICSI的胎儿畸形率为4.4%(8/183),明显高于IVF组的1.1%(6/530)(P<0.05)。母亲年龄<35岁、单胎妊娠、男性胎儿以及移植单个优质胚胎是ICSI胎儿畸形率比IVF组高(P<0.05或0.01)。在胎儿不同系统(肌肉骨骼、消化、泌尿系统、神经管畸形、染色体异常)中,ICSI-ET的胎儿畸形率略高于IVF,但差异无统计学意义(P。结论 >0.05)体外受孕治疗中ICSI-ET可能会增加胎儿畸形的风险,但与胎儿畸形类型无关。

Objective To investigate the influence factors of fetal malformation assisted by two kinds of assisted reproductive technology.Methods Clinical data of maternal women receiving in vitro fertilization or intracytoplasmic sperm injection-embryo transfer(ICSI)at the Center for Reproductive Medicine of the Affiliated Hospital of Guangdong Medical University and their offspring were retrospectively analyzed,including 530 cases of IVF and 183 cases of ICSI.The relevant factors affecting fetal malformation were analyzed.Results The fetal malformation rate of ICSI Group was 4.4%(8/183),which was significantly higher than that of the IVF Group(1.1%,6/530)(P<0.05).The age of mothers<35 years,singleton pregnancy,male fetuses and transfer of single high-quality embryos,the fetal malformation rate of ICSI was higher than that of the IVF group(P<0.05 or<0.01).In different systems of fetuses(musculoskeletal,digestive and urinary system,neural tube defects,and chromosomal abnormalities),the fetuses in the ICSI Group had the fetal deformation rate slightly higher than IVF Group,but the difference was not statistically significant(P>0.05).Conclusion ICSI may increase the risk of fetal malformation,but the specific system that causes fetal malformations still needs to be further evaluated by increasing the sample size.