阿替普酶联合优瑞克林治疗急性脑梗死的临床疗效及安全性分析

Analysis of Clinical Curative Effect and Safety of Alteplase and Urinary Kallidinogenase in Treatment of Acute Cerebral Infraction

目的探讨阿替普酶联合优瑞克林治疗急性脑梗死的临床疗效及安全性。方法根据随机数字表法将方便选取的2015年1月—2018年2月200例急性脑梗死患者分成不同组。对照组给予阿替普酶治疗,观察组则给予阿替普酶联合优瑞克林治疗。比较两组急性脑梗死治疗效果;生命体征稳定时间、出院时间;治疗前后患者神经功能缺损程度;治疗副作用率。结果观察组急性脑梗死总有效率90例(90.00%)高于对照组70例(70.00%),(χ~2=13.520 0,P<0.05)。观察组生命体征稳定时间、出院时间(5.11±1.42)d、(12.13±0.24)d优于对照组(8.41±2.25)d、(15.23±1.51)d,(P<0.05);治疗后观察组神经功能缺损程度(10.33±1.20)分优于对照组(15.19±1.33)分,(t=8.233,P<0.05)。观察组治疗副作用率12例(12.00%)和对照组15例(15.00%)差异无统计学意义(χ~2=0.634,P>0.05)。结论阿替普酶联合优瑞克林治疗急性脑梗死的临床疗效及安全性高,可有效改善神经功能缺损程度和血流动力学情况,且无严重不良反应,安全有效,值得推广应用。

Objective To study the clinical curative effect and safety of alteplase and urinary kallidinogenase in treatment of acute cerebral infraction.Methods200cases of patients with acute cerebral infraction admitted and treated in our hospital from January2015to February2018were convenient selected and randomly divided into two groups,the control group were treated with alteplase,while the observation group were treated with alteplase and urinary kallidinogenase,and the treatment effect,steady time of vital signs,discharged time,nerve function defect degree before and after treatment and side effect rate were compared between the two groups.Results The treatment effect in the observation group was higher than that in the control group,90cases(90.00%) vs70cases(70.00%),(χ^2=13.5200,P<0.05),and the steady time of vital signs and discharged time in the observation group were better than those in the control group,[(5.11±1.42)d,(12.13±0.24)d vs(8.41±2.25)d,(15.23±1.51)d,P<0.05],after treatment,the nerve function defect degree in the observation group was better than that in the control group,[(10.33±1.20)points vs(15.19±1.33)points,t=8.233,P<0.05)],and the difference in the treatment side effect rate in the observation group and in the control group was not obvious,[12case(12.00%)vs15case(15.00%),χ^2=0.634,P>0.05].Conclusion The clinical curative effect and safety of alteplase and urinary kallidinogenase in treatment of acute cerebral infraction are high,which can effectively improve the nerve function defect degree and hemodynamics,without serious adverse reactions,and it is safe and effective,and it is worth promotion and application.