抗VEGF药物治疗不同病程湿性年龄相关性黄斑变性的临床疗效分析

Analysis of Clinical Curative Effect of Anti VEGF Drugs in Treatment of Wet Age-related Macular Degeneration in Different Stages

目的该次研究主要针对不同病程湿性年龄相关性黄斑变性借助抗VEGF药物进行治疗的具体效果进行分析。方法该次研究按照对比治疗的模式展开,方便选取的病例按照患者病程进行分组,均为苏州吴江区第一人民医院接诊患者,其中54例(共计54只患眼),其患病时间在6月以下,即观察组,另54例(共计54只患眼),其患病时间在6～12月,即对照组。两组患者均为该院在2016年5月—2018年3月所接诊,且均借助抗VEGF治疗,针对疗效间差异加以分析。结果结合对两组患者ETDRS量表评估可知,在用药前两组差异有统计学意义(P<0.05);而在分别用药3月后,观察组视力表为(14.65±1.06)改善情况显著优势对照组(t=12.579,P<0.05);且结合对患者CRT测量可知,观察组减少量(156.56±2.07)μm同样优于对照组(t=17.078,P<0.05)。结论就湿性年龄相关性黄斑变性而言,病变时间在6月以下患者使用抗VEGF恢复更为理想,可帮助其视力得到有效改善,对于提升患者生活质量同样存在有积极意义。

Objective To analyze the specific effect of anti VEGF drugs in treatment of wet age-related macular degeneration in different stages.Methods The cases were divided into groups with54cases in each,including the observation group(54affected eyes)whose prevalence time was below6months,and the control group(54affected eyes)whose prevalence time was6-12months,and the patients were convenient selected and diagnosed in our hospital from May2016to March2018,and treated with anti-VEGF,and the difference in the curative effect was analyzed.Results The ETDRS scale evaluation showed that there was obvious difference between the two groups before medication(P<0.05);after3months of medication,the vision table in the observation group was(14.65±1.06),and the improvement condition in the observation group was obviously better than that in the control group,(t=12.579,P<0.05),and the CRT measurement showed that the decrease volume in the observation group was(156.56±2.07)μm,which was better than that in the control group(t=17.078,P<0.05).Conclusion The recovery effect of anti-VEGF of patients whose lesion time was below6months is more ideal,which can help the patients improve the vision effectively,and it is of positive significance to improving the quality of life.