面向电阻抗成像检测的多电极阵列微流控芯片设计

Design of Multi-Electrode Array Microfluidic Chip for Electrical Impedance Tomography

设计了一种用于微尺度流动状态下电阻抗成像检测的多电极阵列微流控芯片,包括微流控芯片的结构设计、材料选择和加工工艺。设计的微流控芯片包含3个圆形电极横截面,每个横截面包含一组电极阵列。该阵列有3种数目的电极,分别为8电极,12电极和16电极。之后通过数值仿真方法实现了3种电极数目(8,12和16)微流控芯片的电阻抗成像,并与之前研究出来的菱形横截面8电极微流控芯片进行了对比,发现设计出来的16电极圆形微流控芯片具有较高的成像质量,验证了微流控芯片用于细胞电阻抗成像检测的可行性。

A multi-electrode array microfluidic chip for electrical impedance imaging detection in micro-scale flow state is designed,including the structure design,material selection and processing technology of the microfluidic chip.The designed microfluidic chip contains3cross-sections,each of which contains a set of electrode arrays.The array has3types of electrodes,namely,8-electrode,12-electrode,and16-electrode.Afterwards,the three types of cross-sectional electrical impedance imaging of the microfluidic chip were realized by numerical simulation method.Compared with the previous diamond-shaped8-electrode,the designed16-electrode microfluidic chip has high imaging quality.The feasibility of the microfluidic chip for the detection of cellular impedance imaging was verified.