从“痰”论治胃癌的中西医结合实践

Integrated traditional Chinese and Western medicine in treatment of gastric cancer:practice of phlegm syndrome theory

中医药是我国恶性肿瘤综合防治领域的特色与优势。海军军医大学(第二军医大学)长征医院中医科在长期临床实践中提出"痰"是贯穿胃癌全过程的核心病机,并结合实验和临床研究,构建了阐释胃癌病机的"胃癌痰证"理论,创制了以消痰为主的系列治法与方药。在"胃癌痰证"理论指导下,消痰方药可明显提高胃癌患者的生活质量,改善其免疫功能,延长生存期。本文介绍了"胃癌痰证"理论及消痰方药的治疗效果,并从肿瘤细胞增殖、凋亡、表观遗传学异常、侵袭转移、肿瘤微环境等角度阐释了消痰方药治疗胃癌的可能分子机制,深化了中医药防治胃癌的科学内涵。

Traditional Chinese Medicine has its characteristics and advantages in the comprehensive prevention and treatment of malignant tumors.Based on long-time clinical practices and experimental studies,Department of Traditional Chinese Medicine of Changzheng Hospital of Navy Medical University(Second Military Medical University)established that“phlegm”is the core pathogenesis throughout the whole process of gastric cancer,and developed a theory of“phlegm syndrome of gastric cancer”and a series of prescriptions for eliminating phlegm.The therapeutic regimen based on this theory can significantly improve the quality of life and immune function and prolong the survival of patients with gastric cancer.This review introduces the theory of“phlegm syndrome of gastric cancer”and the treatment effect of eliminating phlegm prescriptions and drugs,elucidates their possible molecular mechanisms from the aspects of gastric cancer cell proliferation,apoptosis,epigenetic abnormalities,metastasis and tumor microenvironment,hoping to deepen the understanding of traditional Chinese medicine in comprehensive treatment of gastric cancer.