IP10对HIV/AIDS患者免疫激活作用的研究进展

Advances of IP10 on immune activation in HIV/AIDS patients

HIV感染者即使接受了规律有效的抗病毒治疗,其体内仍然存在慢性长期的免疫激活,这已被证明是引起许多HIV相关非AIDS并发症的重要原因。其中固有免疫激活系统产生的趋化因子干扰素-γ诱导蛋白10(interferon gammainduced protein 10, IP10)近年来在HIV研究领域受到更多的关注。IP10是一种由干扰素刺激基因产生的趋化蛋白,在HIV感染者疾病进展,与HIV感染者体内的适应性免疫系统相互作用,影响病毒储存库,引起非AIDS相关并发症方面起到重要作用。降低IP10水平或可为HIV感染者的治疗提供新的思路,为AIDS的功能性治愈奠定基础。

Even if HIV-infected patients receive regular and effective antiviral therapy,there is still chronic long-term immune activation in their body,which has been proved to be an important cause of many HIV associated non-AIDS complications.Interferon gamma-induced protein10(IP10),which is produced by the innate immune activation system,has attracted more attention in the field of HIV research in recent years.IP10is a chemotactic protein produced by interferon-stimulated genes and plays an important role in HIV-infected disease progression,interaction with adaptive immune systems in HIV-infected individuals,affecting viral reservoirs and causing HIV associated non-AIDS complications.Reducing the level of IP10may provide new ideas for the treatment of HIV-infected patients and lay the foundation for functional cure of AIDS.