HIV病毒库清除策略中潜伏逆转剂的应用及挑战

Application and challenges of latent reversal agent in elimination strategy of latent HIV reservoir

高效抗反转录病毒治疗能够有效抑制HIV复制,但患者须终身服药且不能清除病毒库。通过激活和清除策略有望彻底清除病毒库。本文对潜伏逆转剂及潜伏病毒库清除策略的基础及临床研究的进展进行综述。

Despite the success of highly active antiretroviral therapy in suppressing HIV replication,treatment is lifelong and it cannot completely eliminate latent reservoir.“Shock and Kill”strategy is potential for purging the reservoir of HIV.This paper reviews the progress on basic and clinical studies in latency-reversing agent and the elimination strategy of latent reservior.