十字花科蔬菜膳食摄入、尿液中异硫氰酸盐水平与男性胃癌关系的巢式病例对照研究

Association between dietary cruciferous vegetables,urinary isothiocyanates level and gastric cancer risk in men: A nested case-control study

【目的】探讨膳食十字花科蔬菜(CV)摄入、尿液异硫氰酸盐(ITC)代谢与男性胃癌发病风险的关系。【方法】以上海男性健康队列为基础,采用巢式病例对照设计,选择诊断时间在2010年12月31日之前的胃癌新发病例291例作为病例组,按照1︰2的比例抽取对照582例。膳食CV摄入量根据食物频率问卷估计,尿液ITC代谢量通过高效液相色谱法测定。采用非条件logistic回归模型分析这两个指标与男性胃癌的关系。【结果】比较病例组和对照组的膳食CV摄入量和尿液ITC代谢量,未发现两组间差异具有统计学意义。尿液ITC代谢量根据对照组划分三组,调整年龄、吸烟、饮酒、慢性胃病等混杂因素后,与最低组相比较,较高组和最高组的OR(95%CI)值分别为0.94(0.66~1.34)、1.01(0.71~1.43),两者关联无统计学意义。采用同样的分析方法,也未发现膳食CV摄入量与胃癌的发病有关。【结论】在上海市男性居民中,十字花科蔬菜摄入、尿中ITC水平与胃癌之间无统计学关联。

[Objective]To explore the association between intake of cruciferous vegetables(CV),level of urinary isothiocyanates(ITC)and the risk of male gastric cancer in urban Shanghai.[Methods]A nested case-control study was conducted within the Shanghai Men's Health Study.Incident gastric cancer cases(N=291)were diagnosed prior to December31,2010.With a2︰1control to case ratio,582controls were selected from cohort members.Dietary CV consumption was calculated using a food-frequency questionnaire.Urinary ITC level was measured by the high performance liquid chromatography method.Unconditional logistic regression model was used to evaluate the relationship of CV intake and ITC level with the risk of male gastric cancer.[Results]Neither the dietary CV intake nor urinary ITC level differed significantly between cases and controls.Categorical data analysis based on tertiles of controls also showed no significant association between them.Compared to the lowest tertile,the OR(95%CI)for the second and third tertile of urinary ITC level were0.94(0.66-1.34)and1.01(0.71-1.43),respectively,after adjustment for age,smoking,alcohol consumption and chronic stomach diseases.Similar analyses for dietary CV intake showed null association.[Conclusion]Cruciferous vegetables intake and urinary isothiocyanates level were not associated with risk of gastric cancer among men in urban Shanghai.