孟鲁司特钠辅助治疗咳嗽变异性哮喘患儿的效果及对血清炎症因子的影响

Effect of montelukast sodium in adjuvant treatment of children with cough variant asthma and its effect on serum inflammatory factors

目的探讨孟鲁司特钠辅助治疗咳嗽变异性哮喘患儿的效果及对血清炎症因子的影响。方法将我院2015年3月～2017年5月收治的150例患有咳嗽变异性哮喘的患儿,依照系统随机化法分为雾化吸入组和辅助用药组各75例。雾化吸入组给予常规基础治疗配合雾化吸入治疗,辅助用药组在雾化吸入组基础上辅助使用孟鲁司特钠进行治疗,对两组患儿治疗后的临床效果和治疗前后临床症状评分及肿瘤坏死因子-α(TNF-α)、免疫球蛋白E(IgE)和降钙素原(PCT)等炎症因子指标进行比较分析。结果治疗后辅助用药组总有效率(96.00%)高于雾化吸入组(78.33%),差异有统计学意义(P <0.05);治疗后两组患儿临床症状评分均低于治疗前,且辅助用药组评分明显低于雾化吸入组(P <0.05);治疗后两组患儿TNF-α、Ig E和PCT水平均低于治疗前,且辅助用药组水平低于雾化吸入组(P <0.05)。结论孟鲁司特钠对辅助治疗咳嗽变异性哮喘的患儿作用显著,能有效提高治疗效果,患儿临床症状改善较明显,炎症因子水平能得到有效控制。

Objective To explore effect of montelukast sodium in adjuvant treatment of children with cough variant asthma and its effect on serum inflammatory factors.Methods One hundred and fifty children with cough variant asthma who were admitted and treated in our hospital from March 2015 to May 2017 were divided into the aerosol inhalation group and the adjuvant drug group according to the systematic randomization method,with 75 cases in each group.The aerosol inhalation group was given conventional basic treatment combined with aerosol inhalation while the adjuvant drug group was treated by montelukast sodium at basis of the aerosol inhalation group.Clinical effect after treatment of children in two groups were compared and analyzed.Clinical symptom score and Inflammatory factor indexes such as tumor necrosis factorα(TNF-α),immunoglobulin E and procalitonin(PCT)before and after treatment were also compared and analyzed.Results The total effective rate in the adjuvant drug group was 96.00%,higher than that in the aerosol inhalation group 78.33%.The difference was statistically significant(P<0.05).Clinical symptom score after treatment of children in two groups were both lower than that before treatment and clinical symptom score of the adjuvant drug group was significantly lower than that of the aerosol inhalation group(P<0.05).TNF-α,IgE and PCT levels after treatment of children in two groups were lower than those before treatment and the levels in the adjuvant drug group were lower than those in the aerosol inhalation group(P<0.05).Conclusion Montelukast sodium in adjuvant treatment of children with cough variant asthma has a significant adjuvant effect,which can effectively improve the therapeutic effect,improve clinical symptoms of children is obvious and effectively control level of inflammatory factors.