壳聚糖接枝聚赖氨酸苄酯负载紫杉醇纳米胶束的制备及性能研究

Preparation and Properties of Chitosan Grafted Poly (Lysine Benzyl Ester) Loaded Paclitaxel Micelle

[目的]:利用自主装法制备载紫杉醇纳米胶束。[方法]:以壳聚糖接枝聚赖氨酸苄酯作为载体负载紫杉醇,通过自主装的方法制备载药胶束,通过体外释放实验考察载药胶束中紫杉醇的释放规律,通过Zeta电位粒径测定仪测定载药胶束的粒径。[结果]:通过自主装的方法能够顺利制备得到紫杉醇载药胶束,体外释放实验表明紫杉醇在纳米胶束中的释放包含了一个快速释放及一个缓慢释放的过程。载药胶束的粒径范围在40-120nm之间。

[Purpose]:Paclitaxel loaded micelles were prepared by self loading method.[Methods]:Paclitaxel-loaded micelles were prepared by self-loading method with chitosan grafted poly(L-L-benzyl ester)as carrier.The release of paclitaxel in the drug-loaded micelles was investigated in vitro.The particle size of the drug-loaded micelles was determined by Zeta potential particle size analyzer.[Results]:Paclitaxel-loaded micelles were successfully prepared by self-loading method.In vitro release experiments showed that paclitaxel release in micelles included a rapid release and a slow release process.The size range of drug loaded micelles is between40-120nm.