IL-6与慢性阻塞性肺疾病关系的研究进展

Research Progress in Relationship between Interleukin-6 and Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是一种炎症介导的以气道重塑和肺实质破坏为特征的疾病。长期吸烟、呼吸道频繁感染、气道反应性增高等因素导致多种炎性细胞和细胞因子在呼吸道和(或)肺内活化、聚集、浸润炎症部位,释放各种炎性介质,导致气道和(或)肺实质结构和功能异常。其中,对白细胞介素6(IL-6)的研究较为成熟,IL-6主要由单核巨噬细胞、血管内皮细胞、辅助性T细胞等多种细胞产生,具有复杂的生物效能,对COPD的炎症过程有重要意义,并与COPD的发病机制密切相关。

Chronic obstructive pulmonary disease(COPD)is a disease characterized by inflammation-mediated airway remodeling and lung parenchymal destruction.Long-term smoking,recurrent respiratory infections and airway hyper-responsiveness,etc.cause a variety of inflammatory cells and cell factors to activate,aggregate and infiltrate in the inflammation sites of the airway and/or lung,thereby releasing various inflammatory mediators,leading to changes in the airway and/or lung structure and function.Among them,the study of interleukin-6(IL-6)is relatively mature.IL-6 is mainly secreted by monocytes,macrophages,vascular endothelial cells,helper T cells and other cells.It has a complex biological role and is important for the inflammatory process of COPD,and is closely related to the pathogenesis of COPD.