老年糖尿病血和肽素、胱抑素C与冠脉病变相关性研究

Correlation between cystain C and copeptin and coronary artery culprit lesions in patients of elderly diabetes with coronary artery disease

目的探讨血胱抑素C(Cys C)和肽素(CPP)水平与老年2型糖尿病(T2DM)合并冠脉病变严重程度的相关性。方法收集老年2型糖尿病患者125例,均行冠脉造影,根据冠脉造影结果分成冠脉正常组(DM1)和冠脉病变组,根据Gensini评分将冠脉病变组分三个亚组:DM2组(0分<Gensini评分<20分),DM3组(20≤Gensini评分≤40分),DM4组(Gensini评分> 40分)。各组均检测血胱抑素C和血和肽素水平。各组数据进行统计学分析。结果 (1)四组间血糖化血红蛋白(Hb A1c),Cys C,CPP比较差异有统计学意义(P <0. 05)。(2)各组间年龄、性别、吸烟史差异均无统计学意义(P>0. 05)。(3)Cys C,CCP,Hb A1c与冠状动脉狭窄评分呈正相关。结论老年2型DM血Cys C,CCP水平与冠脉病变严重程度存在相关性,有可能成为早期预测老年T2DM患者发生冠脉病变的生物学指标。

Objective To investigate the correlation between the serum cystatin C、Copeptin and the severity of coronary artery lesions in patients of type2diabetes with coronary heart disease.Methods A total of125patients with diabetes,Each patient underwent coronary angiography,The levels of serum cystatin C and Copeptin were measured by ELISA,and the data were analyzed statistically.According to coronary angiography,it was divided into coronary artery disease group and.Coronary normal group,According to the Gensini international scoring standard to calculate Gensini in the coronary artery disease group,record the number of coronary lesions,and the data were analyzed statistically.Results①HbA1c,cystatin C,Copeptin and Gensini score was statistically significant between DM1,DM2,DM3,DM4group(P<0.05).②The age,sex,smoking history showed no statistical differences between the group.(P>0.05).③Cys C、CCP、HbA1c were positively correlated with the score of coronary artery injury.Conclusion There is a correlation between Cys CJ CCP level and severity of coronary artery disease in elderly patients with T2DM,which may be a biological index for early prediction of coronary artery disease in elderly patients with T2DM.