多索茶碱治疗老年支气管哮喘急性发作期的疗效分析

Analysis on the efficacy of doxofylline in the treatment of elderly patients with acute attack of bronchial asthma

目的探讨多索茶碱治疗老年支气管哮喘急性发作期的临床疗效及安全性。方法随机将76例老年支气管哮喘急性发作期患者分为观察组和对照组,各38例。在常规治疗基础上,对照组静脉滴注氨茶碱,观察组静脉滴注多索茶碱。观察两组临床疗效、症状和肺功能改善情况以及不良反应发生情况。结果观察组、对照组总有效率分别为92. 14%和71. 05%,差异有统计学意义(P <0. 05)。观察组喘息、咳嗽、湿啰音、哮鸣音等症状改善情况优于对照组(P <0. 01)。治疗后,两组第1秒用力呼气量(FEV1)、FEV1/用力肺活量(FEV1/FVC)、晨间最大呼气流量(PEFam)、晚间最大呼气流量(PEFpm)均较治疗前明显升高(P <0. 01),但观察组升高程度更为显著(P <0. 05)。观察组不良反应发生率为5. 26%,明显低于对照组的26. 34%(P <0. 05)。结论多索茶碱可有效缓解老年支气管哮喘急性发作期患者的哮喘症状,改善肺功能,疗效及安全性均优于氨茶碱。

Objective To explore the clinical efficacy and safety of doxofylline in the treatment of elderly patients with acute attack of bronchial asthma.Methods Totally76elderly patients with acute attack of bronchial asthma were randomly divided into observation group and control group,38cases in each group.Based on the routine treatment,the control group was given intravenous drip of aminophylline,while the observation group given doxofylline.The clinical efficacy,symptoms,lung function and adverse reactions were all compared between two groups.Results The overall response rates of observation group and control group were92.14%and71.05%,respectively,with statistical significance(P<0.05).The improvement of symptoms including panting,cough,moist rales and wheezing in observation group was superior to that in control group(P<0.01).After treatment,the forced expiratory volume in1s(FEV1),FEV1/forced vital capacity(FVC),peak expiratory flow in the morning(PEF am)and at night(PEF pm)were elevated dramatically in two groups when compared with pre-treatment(P<0.01),but the elevated degree of observation group was more significant(P<0.05).The incidence of adverse reactions was5.26%in observation group,markedly lower than26.34%in control group(P<0.05).Conclusion Doxofylline can effectively alleviate the asthmatic symptoms and improve the lung function in elderly patients with acute attack of bronchial asthma,with the efficacy and safety superior to aminophylline.