动态血压监测仪观察不同药物治疗原发性高血压的疗效分析

Therapeutic Effect Observing of Different Medication of Primary Hypertension based on Dynamic Blood Pressure Monitor

目的对比分析硝苯地平缓释片与硝苯地平控释片在治疗原发性高血压时的作用。方法一共选至我院2016年12月～2017年12月287位患有原发性高血压的病人,一共分成a、b两个组,a组有160人,b组127人。其中a组患者服用硝苯地平缓释剂进行治疗,每次20 mg,一天两次。b组患者使用硝苯地平控释剂进行治疗,每次30 mg,一天服用一次,7个星期后对动态血压进行检测,对a组和b组的人员在治疗前后的血压情况和24 h的平均血压情况进行分析。结果在进行药物治疗之前,a、b两组的患者的血压差差异无统计学意义(P>0.05)。在进行治疗之后b组患者的舒张压、收缩压、24 h之内的平均舒张压和a组相对比,a、b两组之差异具有统计学意义(P<0.05),两组患者治疗前后的情况差异具有统计学意义(P<0.01),两组的不良反应差异无统计学意义(P>0.05)。结论硝苯地平缓释片与硝苯地平控释片在高血压的治疗方面都有降低血压的功能,但硝苯地平控释片的治疗性能更高。

Objective To compare and analyze the effect of nifedipine sustained release tablets and nifedipine controlled release tablets in the treatment of primary hypertension.Methods A total of287patients with primary hypertension from December2016to December2017in our hospital were selected,which were divided into two groups,group a and b,with160patients in group a and127patients in group b.Group a patients were treated with nifedipine sustained-release agent,20mg each time,twice a day.Patients in group b were treated with nifedipine controlled release agent,30mg each time,once a day,and their dynamic blood pressure was tested7weeks later.The blood pressure of group a and group b before and after treatment and the average blood pressure of24hours were analyzed.Results Before drug treatment,there was no significant difference in blood pressure between group a and group b(P>0.05).After treatment,the difference between group a and group b was statistically significant(P<0.05)while comparation was performed in patients with diastolic blood pressure,systolic blood pressure and the mean diastolic pressure within24h.The situation of the two groups of patients before and after treatment was statistically significant(P<0.01).There was no significant difference between two groups of adverse reaction(P>0.05).Conclusion Both nifedipine sustained release tablets and nifedipine controlled release tablets have the function of lowering blood pressure in the treatment of hypertension,but nifedipine controlled release tablets have higher therapeutic performance.