非酒精性脂肪肝病的影像学定量评估研究进展

Advances in quantitative imaging evaluation of non-alcoholic fatty liver disease

非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感性密切相关的代谢应激性肝脏损伤,是与肥胖、2型糖尿病、高血压、血脂异常相关的临床和病理改变,部分病例可以进展为肝纤维化、肝硬化、甚至肝功能衰减和肝细胞癌,所以早期通过无创性方法定量诊断非酒精性脂肪肝病对临床干预具有非常重大的意义。该文对超声、CT和MR成像在脂肪定性、定量诊断中的研究现状和进展进行综述。

Non-alcoholic fatty liver disease(NAFLD)is a metabolic stress liver injury which is closely related to insulin resistance(IR)and genetic susceptibility.It is related to the clinical and pathological changes of obesity,type2diabetes,hypertension and dyslipidemia.Some cases may advance to liver fibrosis,liver cirrhosis,even attenuation of liver function,and hepatocellular carcinoma.Therefore,the early quantitative diagnosis of nonalcoholic fatty liver disease by non-invasive method is of great significance for clinical intervention.In this paper,the current research status and progress of ultrasound,computed tomography(CT)and magnetic resonance imaging(MRI)in the qualitative and quantitative diagnosis of fat are reviewed.