EGCG抗肿瘤作用及其相关靶点的研究进展

Research progress of anti-tumor effect of EGCG and its related targets

表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)是绿茶的主要生物活性成分,是一种多酚类物质,属于茶多酚的一种。多年来研究发现其在抗氧化、抗炎、抗心血管疾病、抗肥胖、抗糖尿病、抗神经系统疾病、抗肿瘤等等方面发挥了预防及潜在的治疗作用,并可与多种蛋白靶点作用,影响多种化学通路发挥其上述生物学作用,如跟自噬相关蛋白LC3-Ⅰ直接结合促进LC3-Ⅱ的形成进而促进自噬,作用于PI3K/AKT通路影响细胞自噬、细胞凋亡、血管生成和细胞周期调控等等。现对其在抗肿瘤方面的作用及其相关靶点作一综述。

Epigallocatechin gallate( EGCG) is the main bioactive component of green tea and is a polyphenolic substance that belongs to the class of tea polyphenols. Over the years,it has been discovered that it has played a preventive and potential therapeutic role in anti-oxidation,anti-inflammatory,anti-cardiovascular diseases,anti-obesity,anti-diabetic,anti-neurological diseases,anti-tumor,and so on. It can interact with multiple protein targets and affect various biological pathways to exert its biological effects. For example,direct binding to autophagy-related protein LC3-Ⅰ promotes the formation of LC3-Ⅱ and promotes autophagy,acting on the PI3K/AKT pathway to affect cell autophagy,apoptosis,angiogenesis,and cell cycle regulation. Its anti-tumor role and its related targets are reviewed.