血吸虫肠病相关性结直肠癌的研究进展

Research progress of colorectal cancer with schistosomiasis

日本血吸虫感染曾经是中国较为严重的流行病,同时也是引起结直肠癌(colorectal cancer,CRC)发生的原因之一。CRC的患者若有血吸虫病感染史,术前肠道具有血吸虫感染相关的影像学表现,术后病理证实肿瘤附近有虫卵沉积,则可定义为血吸虫肠病相关性CRC(colorectal cancer with schistosomiasis,CRCS)。探究血吸虫肠病到CRCS之间演变的炎癌转化机制,对于改善CRCS预后尤为重要。笔者结合国内外的最新研究报道,对CRCS发病机制、病理特征以及临床研究进展进行综述,以期为CRCS防治提供帮助,亦为炎癌转化研究提供新的思路。

Schistosomiasis was once an extremely serious epidemic in China,at the same time,it was also one of the causes of colorectal cancer(CRC).Colorectal cancer patients who had a history of schistosomiasis infection,preoperative imaging findings,the deposit of eggs near the tumor in postoperative pathology,can be defined as colorectal cancer with schistosomiasis(CRCS).It is great important to explore the mechanism of the evolution from schistosomiasis intestinal disease to CRCS and to improve the prognosis of CRCS.In this paper,the authors summarized the up-to-date research progresses on the pathogenesis,pathological characteristics and clinical research progress of CRCS in China and overseas to provide the preventions and treatments of CRCS,and to provide new ideas for the transformation of inflammatory cancer.