Lamin A/C在干细胞表观遗传药理学中的调控作用

Regulation of Lamin A/C in epigenetic pharmacology of stem cells

Lamin A/C是核纤层的主要组成部分,在干细胞表观遗传调控中的重要作用近年来越来越被认识。Lamin A/C不仅可以起到维持核内稳态和保护染色质的作用,同时也可以作为机械刺激细胞核内的反应器,将力学信号传导至核内,可直接或间接参与基因的转录调控。该文主要综述微环境中力学信号对干细胞Lamin A/C的调节,以及Lamin A/C的功能变化对染色体修饰、基因表达调控的影响。

Lamin A/C is the main component of nuclear lamina,and its important role of epigenetic pharmacology in stem cells has been recognized in recent years.Lamin A/C has been reported to maintain the nuclear homeostasis,protect the chromatin,and act as a reactor for mechanical stimulation of the nucleus to transmit mechanical signals.Besides,Lamin A/C has been discovered to participate directly or indirectly in the transcriptional regulation of the genes.This article aims to review the regulation of Lamin A/C in stem cells by mechanical signals of microenvironment,and the effect of Lamin A/C on chromosome modification and genes regulation.