藏药二十五味珊瑚丸治疗阿尔茨海默病的网络药理学研究

A network pharmacology study on mechanism of Tibetan medicine Byur d Mar Nyer lNga Ril Bu against Alzheimer's disease

目的通过网络药理学方法 ,探讨藏药二十五味珊瑚丸治疗阿尔茨海默病的药理作用机制。方法采用反向药效团匹配法,对二十五味珊瑚丸主要入血成分的潜在靶点进行预测,并结合生物信息学手段,对主要生物学功能及细胞信号通路进行系统分析。结果二十五味珊瑚丸作为一种多组分药物,具有多个潜在靶点。可能参与以丝裂原活化蛋白激酶、胰岛素、哺乳动物雷帕霉素靶蛋白为主的细胞信号传导通路,涉及以炎症、凋亡、β淀粉样蛋白的表达及清除为主的生物学功能。结论二十五味珊瑚丸能够通过多组分和多靶点的协同作用,共同干预阿尔茨海默病的进程。

Aim To investigate the underlying pharmacological mechanism of Tibetan medicine Byur dMar25(BM25)in the treatment of Alzheimer′s disease(AD)based on network pharmacology approaches.Methods The potential target of the main blood components after oral administration of BM25was predicted through reverse pharmacophore mapping scheme,and the main biological functions and cell signaling pathways were systematically analyzed based on bioinformatics strategies.Results BM25,as a multi-component drug with numerous potential targets may mainly participate in MAPK,insulin,mTOR signaling pathways,contributing to different biological functions including inflammation,apoptosis,and expression and clearance of beta amyloid(Aβ).Conclusion BM25could interfere the progress of Alzheimer's disease,and the mechanism is a concerted pharmacological intervention of multiple components and targets.