体检人群中尿酸与心血管病危险因素的相关性研究

Correlation Between Uric Acid and Risk Factors of Cardiovascular Disease in People Under Physical Examination

目的通过对健康体检大数据分析,探讨尿酸与心血管病危险因素(超重与肥胖、高血压、糖尿病、血脂异常)之间的关系。方法采用回顾性研究,选择2017年1—12月在我院进行健康体检者52 673人的资料,统计分析尿酸与心血管病危险因素的关系。结果(1)人群中总体高尿酸血症患病率为20.49%,男性(31.09%)高于女性(8.99%)(P <0.001)。(2)高尿酸血症组人群较尿酸正常组的身体质量指数、血压、血糖、血脂等指标均显著升高(P <0.001),同时超重与肥胖、高血压、糖尿病、血脂异常患病率也显著升高(P<0.001)。(3)简单相关分析结果显示,尿酸与身体质量指数、收缩压、舒张压、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白呈正相关,与高密度脂蛋白呈负相关。在控制各指标进行偏相关分析后,尿酸与空腹血糖、高密度脂蛋白呈负相关,与其它指标仍呈正相关。结论(1)血清尿酸水平与年龄、性别相关,男性尿酸水平和高尿酸血症患病率均高于女性。(2)尿酸与身体质量指数、血压、血糖、血脂等各指标均有一定的相关性,其与心血管病之间的密切关系值得我们进一步深入研究。

Objective To explore the association of uric acid with the risk factors for cardiovascular diseases(obesity,hypertension,diabetes and dyslipidemia)in adults by analyzing big data from people receiving health checkup.Methods This was a retrospective study where data were collected from52673people who had received health checkup from January to December2017;Statistical analysis was performed on uric acid and its association with the risk factors for cardiovascular diseases.Results(1)The prevalence of hyperuricemia was20.49%overall,and was significantly higher in males(31.09%)than in females(8.99%)(P<0.001).(2)Compared with the normal uric acid group,the indicators including BMI,blood pressure,blood glucose and blood lipids were significantly increased in the hyperuricemia group(P<0.001),and the prevalences of obesity,hypertension,diabetes and dyslipidemia were also significantly increased(P<0.001).(3)Simple correlation analysis showed that uric acid was positively correlated with BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting plasma glucose(FPG),triglyceride,total cholesterol and low density lipoprotein cholesterol(LDL-C),and negatively correlated with high density lipoprotein cholesterol(HDL-C).Partial correlation analysis for each indicator showed that uric acid was negatively correlated with FPG and HDL-C,and remained positively correlated with the other indicators.Conclusion(1)Serum uric acid is correlated with age and sex.Uric acid and prevalence of hyperuricemia are higher in males than in females.(2)Uric acid is to some extent correlated with the indicators including BMI,blood pressure,blood glucose and blood lipids,and its close association with cardiovascular disease warrants further studies.