2型糖尿病合并高脂血症患者降脂治疗的临床研究

Clinical Research on Lipid-lowering Therapy in Patients With Type 2 Diabetes Mellitus and Hyperlipidemia

目的探讨2型糖尿病合并高脂血症患者降脂治疗的临床效果。方法选取本院2015年10月—2017年10月诊治的2型糖尿病合并高脂血症患者88例,采用相同的降糖方案,采用随机数字表法分为两组,对照组患者44例采用辛伐他汀片治疗,观察组患者44例采用阿托伐他汀钙片治疗,于治疗前后行血脂[总胆固醇(TC)、甘油三酯(TG)、载脂蛋白A(APOA)、载脂蛋白B(APOB)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]检测,比较两组患者的降脂效果。结果治疗后,两组患者TC、TG、APOB、LDL-C显著降低(P <0.05)。两组患者APOA、HDL-C显著增加(P <0.05)。观察组患者TC、TG、APOB、LDL-C低于对照组(P <0.05)。观察组患者APOA、HDL-C高于对照组(P <0.05)。观察组患者总有效率高于对照组(P <0.05)。结论阿托伐他汀钙片对2型糖尿病合并高脂血症患者的降脂治疗效果显著。

Objective To investigate clinical effect of lipid-lowering therapy in patients with type2diabetes mellitus and hyperlipidemia.Methods88patients with type2diabetes mellitus and hyperlipidemia were selected in hospital from October2015to October2017,who treated the same hypoglycemic protocol.Patients were divided into two groups by random number table method.44patients treated simvastatin tablets as control group.44patients treated atorvastatin calcium tablets as observation group.Blood lipids(TC,TG,APOA,APOB,LDL-C,HDL-C)were detected before and after treatment.Lipid-lowering effect was compared between two groups.Results TC,TG,APOB,LDL-C decreased significantly in two groups after treatment(P<0.05).APOA,HDL-C increased significantly in two groups after treatment(P<0.05).TC,TG,APOB,LDL-C in observation group were lower than control group after treatment(P<0.05).APOA,HDL-C in observation group were higher than control group after treatment(P<0.05).Total effective rate in observation group was higher than control group(P<0.05).Conclusion Atorvastatin calcium tablets have significant lipid-lowering effect in patients with type2diabetes mellitus and hyperlipidemia.