慢性肺源性心脏病急性加重患者在常规治疗基础上加用左卡尼丁对血浆B型钠尿肽及心肺功能、血气状况、血流动力学、凝血功能指标的影响

The effects of CPHD on cardiopulmonary function,blood gas status,hemodynamics,and coagulation function of patients with CPHD were studied on the basis of routine treatment

目的:研究左卡尼丁注射液对慢性肺源性心脏病急性加重患者血浆B型钠尿肽(BNP)的影响及其对慢性肺源性心脏病的疗效。方法:将72例慢性肺源性心脏病患者分成实验组和对照组,对照组患者给予常规治疗,实验组加用左卡尼丁注射液治疗,比较两组患者治疗前和治疗后(一个疗程)BNP水平、心肺功能、血气指标,血液流变学指标以及凝血功能指标。结果:两组患者治疗后血浆BNP水平均较前下降,但注射左卡尼丁的实验组较对照组下降明显(P<0.05);两组患者经过治疗后心肺功能及血气指标均有改善,但注射左卡尼丁的实验组改善情况更明显(P<0.05);常规实验组(对照组)治疗前后血液流变学指标无明显差异,凝血功能尚未有明显改变(P>0.05),左卡尼丁实验组治疗后血液流变学指标明显改善,且患者高凝血得到明显得到缓解(P<0.05)。结论:慢性肺源性心脏病急性加重期患者在常规治疗基础上加用左卡尼丁治疗,可明显降低血浆BNP水平,并可以改善心肺功能、血气指标、血液流变学指标,且能缓解患者高凝血的症状。

objective:to study the l carnitine injection in patients with chronic cor pulmonale with acute aggravating the influence of plasma BNP and its curative effect on chronic cor pulmonale.Methods:72cases of chronic cor pulmonale patients were divided into experimental group and control group in the two groups,control group patients give regular treatment,the experimental group used l carnitine injection treatment,compared two groups of patients before and after the treatment(a course of treatment),cardiopulmonary function,blood gas index,the BNP level indexes of hemorheology and blood coagulation function index).Results:plasma BNP levels after treatment in both groups were compared with the previous fall,but l carnitine injection in the treatment group than the control group decreased significantly(P<0.05);Two groups of patients after heart and lung function and blood gas index were improved after treatment,but l carnitine injection injection treatment group improved more obviously(P<0.05);Routine treatment group(control group)before and after treatment no obvious difference was found between hemorheology indexes,blood coagulation function has not been significant change(P>0.05),l carnitine treatment group after treatment the blood rheology index obviously improved,and patients with high blood coagulation was alleviated obviously(P<0.05).Conclusion:the patients with chronic cor pulmonale with acute aggravating period on the basis of conventional treatment combined with l carnitine treatment,can obviously decrease the plasma BNP level,and can improve cardiopulmonary function,blood gas,hemorheology,and can alleviate the symptoms of patients with high blood coagulation.