热疗联合同步放化疗对中晚期宫颈癌患者血清leptin、IGF2及T细胞亚群水平的影响

Effects of thermotherapy combined with concurrent chemoradiotherapy on serum levels of leptin, IGF2 and T lymphocyte subsets in patients with advanced cervical cancer

目的探讨热疗联合同步放化疗对中晚期宫颈癌患者血清瘦蛋白(leptin)、胰岛素样生长因子2(IGF2)及T细胞亚群水平的影响。方法选取61例中晚期宫颈癌患者,依据随机数字表法将患者分为对照组(n=30)和研究组(n=31),对照组患者接受同步放化疗,研究组患者接受热疗联合同步放化疗。比较两组患者的近期疗效,治疗前后的血清leptin、IGF2、T细胞亚群水平以及不良反应发生情况。结果研究组患者的疾病控制率为100%,高于对照组的86.67%,差异有统计学意义(P﹤0.05)。治疗前,两组患者的血清leptin、IGF2水平比较,差异均无统计学意义(P﹥0.05);治疗后,研究组患者的血清leptin、IGF2水平均明显低于对照组,差异均有统计学意义(P﹤0.01)。治疗前,两组患者的CD3^+、CD4^+和CD8^+水平比较,差异均无统计学意义(P﹥0.05);治疗后,研究组患者的CD3^+、CD4^+水平均高于对照组,CD8^+水平低于对照组,差异均有统计学意义(P﹤0.05)。两组患者骨髓抑制、消化道反应、放射性膀胱炎的发生率比较,差异均无统计学意义(P﹥0.05)。结论热疗联合同步放化疗治疗宫颈癌的近期疗效确切,能够显著降低患者的血清leptin、IGF2水平,改善患者的T细胞亚群水平,且不增加不良反应。

Objective To investigate the effects of thermotherapy combined with concurrent chemoradiotherapy on serum levels of leptin,IGF2 and T cell subsets in patients with advanced cervical cancer.Method Sixty-one patients with advanced cervical cancer were selected,and divided into control group(n=30)and study group(n=31)in accordance with random number table.The patients in control group were treated with concurrent chemoradiotherapy and the patients in study group were treated with thermotherapy combined with concurrent chemoradiotherapy.The short-term efficacy,the serum levels of leptin,IGF2 and T cell subsets of patients,and the adverse reactions were compared between the two groups.Result The total disease control rate was 100%in the study group,which was significantly higher than that of 86.67%in the control group(P<0.05).Before the treatment,there was no significant difference in the levels of leptin and IGF2 between the two groups(P>0.05).After treatment,the levels of leptin and IGF2 in the study group were significantly lower than those in the control group(P<0.01).Before the treatment,there was no significant difference in the levels of CD3^+,CD4^+and CD8^+between the two groups(P>0.05).After treatment,the levels of CD3^+,CD4^+in the study group were significantly higher than those in the control group,the level of CD8+in the study group was significantly lower than that in the control group(P<0.05).There was no significant difference in the incidences of myelosuppression,gastrointestinal reaction or radiocystitis between the two groups(P>0.05).Conclusion Thermotherapy combined with concurrent chemoradiotherapy has significant short-term effect on the treatment of cervical cancer,which can significantly reduce the serum levels of leptin and IGF2,and improve the level of T cell subsets in patients,without increasing adverse reactions.