人滋养层细胞表面抗原-2、细胞周期蛋白D1表达水平对胆囊癌患者组织分化程度的影响

Effects of Human Trophoblast Cell Surface Antigen-2 and Cyclin D1 Expression on Tissue Differentiation in Patients with Gallbladder Carcinoma

目的探究人滋养层细胞表面抗原-2(TROP2)、细胞周期蛋白D1(Cyclin D1)表达水平对胆囊癌患者组织分化程度的影响。方法选取本院2014年6月～2017年12月胆囊癌患者114例设为研究组,组织分化程度:低分化46例,中分化42例,高分化26例。另选同期胆囊良性病变患者117例设为对照组,均检测TROP2、Cyclin D1蛋白表达情况,比较两组TROP2、Cyclin D1阳性表达率,对比研究组不同组织分化程度患者TROP2、Cyclin D1阳性表达率。结果研究组TROP2、Cyclin D1阳性表达率较对照组高(P <0.05);研究组低分化患者TROP2、Cyclin D1阳性表达率较中/高分化患者高(P <0.05)。结论胆囊癌患者TROP2、Cyclin D1呈异常高表达,且组织分化程度越低,其表达越高,可为胆囊癌患者早期诊断及预后情况评估提供参考依据。

Objective To investigate the effects of human trophoblast cell surface antigen-2(TROP2) and cyclin D1(Cyclin D1) expression on the degree of tissue differentiation in patients with gallbladder cancer. Methods A total of 114 patients with gallbladder cancer from June 2014 to December 2017 were enrolled in the study group. The degree of tissue differentiation was 46 with poor differentiation, 42 with moderate differentiation, and 26 with high differentiation. Another 117 patients with benign gallbladder lesions were selected as the control group. The expressions of TROP2 and Cyclin D1 were detected. The positive expression rates of TROP2 and Cyclin D1 were compared between the two groups. The positive expression rates of TROP2 and Cyclin D1 in different tissues of the study group were compared. Results The positive expression rate of TROP2 and Cyclin D1 in the study group was higher than that in the control group(P < 0.05). The positive expression rate of TROP2 and Cyclin D1 in the poorly differentiated patients in the study group were higher than the moderate/highly differentiated patients(P < 0.05). Conclusion The expression of TROP2 and Cyclin D1 in patients with gallbladder carcinoma is abnormally high, and the lower degree of histological differentiation caused the higher expression, which may provide a reference for the early diagnosis and prognosis evaluation of patients with gallbladder cancer.