阿司匹林联合氯吡格雷对脑梗塞的临床治疗效果评价

Evaluation of Clinical Therapeutic Effect of Aspirin Combined with Clopidogrel on Cerebral Infarction

目的探究阿司匹林联合氯吡格雷对脑梗塞的临床治疗效果及不良反应发生率。方法选取2015年1月～2016年1月本院收治的88例脑梗塞患者,按照随机数表法分为对照组、实验组,两组样本病例均为44例,阿司匹林用于对照组中,阿司匹林联合氯吡格雷用于实验组中,分析治两组炎症因子水平、血液流变学指标、神经功能缺损程度、不良反应发生率。结果相较于对照组,炎症因子水平、血液流变学指标实验组较优(P <0.05);相较于对照组,神经功能缺损程度实验组较低,差异有统计学意义(P <0.05)。两组患者均出现头晕、恶心等不良反应,经正确处理后,均能缓解,组间比较差异无统计学意义(P> 0.05)。结论脑梗塞应用阿司匹林联合氯吡格雷治疗,既可缓解神经功能缺损程度,又可改善炎症因子水平、血液流变学指标,临床应用价值较高,值得临床使用。

Objective To investigate the clinical effect and adverse reaction rate of aspirin combined with clopidogrel in cerebral infarction.Methods A total of 88 patients with cerebral infarction admitted to our hospital from January 2015 to January 2016 were randomly divided into control group(n=44)and observation group(n=44).Aspirin was used in the control group,while Aspirin combined with clopidogrel were used in the experimental group.The level of inflammatory factors,hemorheology,neurological deficits,and adverse reactions were analyzed in both groups.Results Compared with the control group,the inflammatory factor level and hemorheology index were superior in the experimental group(P<0.05);The neurological deficit was significantly lower in the experimental group(P<0.05).Both groups experienced adverse reactions such as dizziness and nausea,and they were all relieved after correct treatment.There was no significant difference between the two groups(P>0.05).Conclusions The application of aspirin combined with clopidogrel in cerebral infarction can not only relieve the degree of neurological deficit,but also improve the level of inflammatory factors and hemorheology.It has high clinical value and is worthy of clinical application.