氨基末端脑钠肽前体和D-二聚体与老年急性肺栓塞患者肺动脉高压的相关性分析

Correlation Analysis of NT-pro BNP and D-dimer with Pulmonary Hypertension in the Elderly with Acute Pulmonary Embolism

目的探讨血清氨基末端脑钠肽前体(amino-terminal pro-brain natriuretic peptide, NT-Pro BNP)和D-二聚体与老年急性肺栓塞(acute pulmonary embolism,APE)患者肺动脉收缩压高压(pulmonary hypertension,PH)的相关性。方法入选88例老年APE住院患者,检测血清NT-Pro BNP和D-Dimer水平,比较血清学指标和肺动脉收缩压的相关性。结果 APE无PH组患者NT-Pro BNP水平低于合并肺动脉高压组患者,差异有统计学意义(P<0.01);APE合并中重度PH组患者NT-Pro BNP水平高于轻度PH组,差异有统计学意义(P<0.01)。APE合并中重度PH组患者D-二聚体水平高于无PH组,差异有统计学意义(P<0.05)。血浆NT-Pro BNP和D-二聚体水平均与肺动脉收缩压(pulmonary artery systolic pressure,PASP)水平都呈正相关(r=0.746,r=0.427;P<0.01)。结论 NT-Pro BNP和D-二聚体与APE患者肺动脉高压密切相关,可作为APE患者病情评估及预后判断的参考指标。

Objective To explore the correlation of amino-terminal pro-brain natriuretic peptide(NT-pro BNP)and D-dimer with pulmonary hypertension(PH)in the elderly with acute pulmonary embolism(APE).Methods88hospitalized elderlywith APEwere selected;the serumlevels of NT-pro BNP and D-dimerwere detected,and a comparative study wasmade to the difference in correlation of serum index and pulmonary artery systolic pressure.Results The level of NT-pro BNP in the elderly with APE but no PH was lower than that in the elderly with APE plus PH,the difference was of statistical significance(P<0.01);the level of NT-pro BNP in the elderly with APE plus moderate and severe PH was higher than that in the elderly with APE plus mild PH,the difference was of statistical significance(P<0.01);the level of D-dimer in the elderly with APE plus moderate and severe PH was higher than that in the elderly with APE but no PH,the difference was of statistical significance(P<0.05);the serumlevels ofNT-pro BNP andD-dimerwere positively correlated with pulmonary artery systolic pressure(PASP)(r=0.746,r=0.427;P<0.01).Conclusions The levels of NT-pro BNP andD-dimer are in close correlationwith PHof the elderly with APE,and the serum markers may be the reliable index for disease evaluation and prognosis estimation in the elderly with APE.