摘要
目的探讨血清氨基末端脑钠肽前体(amino-terminal pro-brain natriuretic peptide, NT-Pro BNP)和D-二聚体与老年急性肺栓塞(acute pulmonary embolism,APE)患者肺动脉收缩压高压(pulmonary hypertension,PH)的相关性。方法入选88例老年APE住院患者,检测血清NT-Pro BNP和D-Dimer水平,比较血清学指标和肺动脉收缩压的相关性。结果 APE无PH组患者NT-Pro BNP水平低于合并肺动脉高压组患者,差异有统计学意义(P<0.01);APE合并中重度PH组患者NT-Pro BNP水平高于轻度PH组,差异有统计学意义(P<0.01)。APE合并中重度PH组患者D-二聚体水平高于无PH组,差异有统计学意义(P<0.05)。血浆NT-Pro BNP和D-二聚体水平均与肺动脉收缩压(pulmonary artery systolic pressure,PASP)水平都呈正相关(r=0.746,r=0.427;P<0.01)。结论 NT-Pro BNP和D-二聚体与APE患者肺动脉高压密切相关,可作为APE患者病情评估及预后判断的参考指标。
Objective To explore the correlation of amino-terminal pro-brain natriuretic peptide(NT-pro BNP)and D-dimer with pulmonary hypertension(PH)in the elderly with acute pulmonary embolism(APE).Methods88hospitalized elderlywith APEwere selected;the serumlevels of NT-pro BNP and D-dimerwere detected,and a comparative study wasmade to the difference in correlation of serum index and pulmonary artery systolic pressure.Results The level of NT-pro BNP in the elderly with APE but no PH was lower than that in the elderly with APE plus PH,the difference was of statistical significance(P<0.01);the level of NT-pro BNP in the elderly with APE plus moderate and severe PH was higher than that in the elderly with APE plus mild PH,the difference was of statistical significance(P<0.01);the level of D-dimer in the elderly with APE plus moderate and severe PH was higher than that in the elderly with APE but no PH,the difference was of statistical significance(P<0.05);the serumlevels ofNT-pro BNP andD-dimerwere positively correlated with pulmonary artery systolic pressure(PASP)(r=0.746,r=0.427;P<0.01).Conclusions The levels of NT-pro BNP andD-dimer are in close correlationwith PHof the elderly with APE,and the serum markers may be the reliable index for disease evaluation and prognosis estimation in the elderly with APE.
作者
刘晓鹏
胡志雄
周海英
王静
陆徐峰
Liu Xiaopeng;Hu Zhixiong;Zhou Haiying;Wang Jing;Lu Xufeng(Department of Respiratory Disease, Jinshan Hospital Affiliated to Fudan University, Shanghai, 201508, P. R. China)
出处
《老年医学与保健》
CAS
2018年第6期626-629,共4页
Geriatrics & Health Care
基金
复旦大学附属金山医院院级课题(2018-JSYYKT-01)
关键词
老年
肺栓塞
肺动脉高压
氨基末端脑钠肽前体
D-二聚体
elderly
pulmonary embolism
pulmonary hypertension(PH)
amino-terminal pro-brain natriuretic peptide(NT-pro BNP)
D-dimer