整合素在急性肺损伤中作用与机制的研究进展

Progress on the effect and mechanism of integrins in acute lung injury

急性肺损伤及急性呼吸窘迫综合征死亡率高,其发生机制研究备受关注。整合素广泛表达于细胞表面,与急性肺损伤密切相关。本文对急性肺损伤时整合素家族在调节炎症细胞招募、炎症因子释放和肺泡毛细血管通透性等方面的作用进行综述。

Acute lung injury or acute respiratory distress syndrome has a high mortality.The pathogenesis of acute lung injury has received extensive attention in recent years.Integrins,which express on a wide range of cell surface,are closely related to acute lung injury.This article mainly elaborates the role of integrins in inflammatory cell recruitment,inflammatory cytokines release and alveolar capillary permeability in acute lung injury.