肠黏膜屏障与慢性肾脏病关系的研究进展

Research progress on roles of intestinal mucosal barrier in chronic kidney disease

慢性肾脏病(chronic kidney disease,CKD)常伴发多种并发症,严重危害人类健康。CKD治疗的关键在于减少并发症,延缓CKD的发展及恶化。肠道是应激的中心器官,在创伤、手术、感染等状态下,肠黏膜屏障容易受损,导致肠道细菌易位至其他器官,进而引起局部和全身性炎症反应,甚至多器官功能障碍。近年来,肠黏膜屏障在CKD中的作用越来越受到关注。肠黏膜屏障损伤是CKD并发感染、营养不良等并发症的重要原因。因此,保护肠黏膜屏障功能对延缓CKD的发展,减少并发症具有重要作用。然而,目前CKD时肠黏膜屏障改变的机制仍不明确,故本文就肠黏膜屏障与CKD的关系进行综述。

Chronic kidney disease(CKD)is associated with various complications and causes serious threat to the human health.At present,reducing the occurrence of complications and delaying the progress and deterioration of CKD are considered as the key in the management of CKD.The intestinal tract is regarded as a central target organ leading to various stresses.Under the condition of trauma,surgery,infection,and other stresses,the intestinal mucosal barrier function is subjected to damage and the gut bacteria are translocated from the intestine to other organs,resulting in a local and systemic inflammatory response,even multiple organ dysfunction syndrome(MODS).Currently,the role of intestinal mucosal barrier in CKD receives extensive attentions from researchers.The damage of intestinal mucosal barrier is a very important reason causing the infections,malnutrition,and other complications in advanced CKD.Therefore,the protection of the intestinal mucosal barrier plays an important role in delaying the progress of CKD and reducing the occurrence of complications.However,at present,the mechanism of intestinal mucosal barrier changes in CKD is still unclear.This article aims to review the research progression about the association of intestinal mucosal barrier and CKD.