丹蒌片治疗冠心病痰瘀互结证的疗效及对血清炎性因子的影响

The Efficacy of Danlou Tablet in the Treatment of Coronary Heart Disease with Phlegm and Blood Stasis Syndrome and its Effect on Serum Inflammatory Factors

目的观察丹蒌片治疗冠心病(痰瘀互结证)的疗效及对病人血清炎性因子的影响。方法选取我院2016年1月—2018年1月就诊的冠心病(痰瘀互结证)病人197例,依据治疗方式不同分组。对照组98例采取阿司匹林+阿托伐他汀治疗,研究组99例在对照组基础上采用丹蒌片治疗,比较两组治疗前、治疗1个月后血清分泌型磷脂酶A_2(sPLA_2)、脂蛋白相关磷脂酶A_2(LP-PLA_2)、氧化型低密度脂蛋白(ox-LDL)、单核细胞趋化蛋白-1(MCP-1)水平及世界卫生组织生活质量(WHOQOL-100)评分及两组临床疗效、不良反应发生率。结果治疗1个月后,研究组总有效率93.94%,较对照组79.59%高(P <0.05);血清sPLA_2、LP-PLA_2、ox-LDL、MCP-1水平较对照组降低(P <0.05)。研究组与对照组不良反应总发生率比较,差异无统计学意义(P>0.05)。两组治疗1个月后WHOQOL-100评分均较治疗前升高,且研究组较对照组高(P <0.05)。结论采用丹蒌片治疗冠心病(痰瘀互结证)疗效确切,能显著降低其血清炎性因子水平,提高病人生活质量,且具有安全性。

Objective To observe the curative effect of Danlou tablet(DLT)in the treatment of coronary heart disease(CHD)with phlegm and blood stasis syndrome and on serum inflammatory factors.Methods One hundred and ninety seven patients with CHD and phlegm and blood stasis syndrome in our hospital from January2016to January2018were selected and randomly divided into two groups:control group(n=98)treated with aspirin plus atorvastatin,and study group(n=99)treated with DLT and aspirin plus atorvastatin for1month.The curative effect and incidence of adverse reactions were observed.Serum secretory phospholipase A2(sPLA2),lipoprotein associated phospholipase A2(LP PLA2),oxidized low density lipoprotein(ox-LDL),monocyte chemoattractant protein1(MCP-1)and World Health Organization Quality of Life(WHOQOL-100)scores were compared before and after1month of treatment.Results The total effective rate was93.94%in the study group,which was higher than that in the control group(79.59%,P<0.05).The levels of serum sPLA2,LP-PLA2,ox-LDL and MCP-1in the study group were lower than those in the control group after1month of treatment(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).After1month of treatment,WHOQOL-100scores were higher in two groups,which were higher in the study group than that in the control group(P<0.05).Conclusion DLT can significantly reduce the level of serum inflammatory factors,improve the quality of life in patients with CHD and phlegm and blood stasis syndrome.