阿奇霉素联合糖皮质激素治疗小儿大叶性肺炎

Azithromycin Combined With Glucocorticoids in the Treatment of Pediatric Lobar Pneumonia

目的探究在大叶性肺炎患儿的治疗中应用糖皮质激素和阿奇霉素对临床效果和血清炎性因子的影响。方法将2015年8月—2018年8月我院收治的大叶性肺炎患儿70例均分为两组,对照组单用阿奇霉素治疗,研究组加用糖皮质激素,比较两组在症状改善情况和炎性因子水平方面存在的差异。结果研究组退热、咳嗽缓解、阴影消退的时间均短于对照组(t=9.192、7.181、5.913,P=0.000),且治疗后研究组患者的PCT、CRP炎性因子的水平低于对照组(t=14.199、7.656,P=0.000)。结论将糖皮质激素和阿奇霉素联合应用对大叶性肺炎患儿进行治疗可以使其症状得到改善,降低炎性因子水平,临床效果显著。

Objective To investigate the effects of glucocorticoids and azithromycin on clinical outcomes and serum inflammatory factors in the treatment of children with lobar pneumonia.Methods Seventy children with lobar pneumonia admitted to our hospital from August to August 2018 were divided into two groups.The control group was treated with azithromycin alone.The study group was treated with glucocorticoids.Improvements and differences in levels of inflammatory factors.Results The time of fever,cough relief,and shadow regression in the study group were significantly shorter than those in the control group(t=9.192,7.181,5.913,P=0.000),and the PCT and CRP inflammatory factors were significantly higher in the study group after treatment.Lower than the control group(t=14.199,7.656,P=0.000).Conclusion The combination of glucocorticoid and azithromycin in the treatment of children with lobar pneumonia can significantly improve the symptoms,reduce the level of inflammatory factors,and the clinical effect is significant.