探讨血清指标与2型糖尿病早期肾损伤的关系

The Relationship Between Glycosylated Hemoglobin, Glycated Albuminand and Early Kidney Injury in Patients With Type 2 Diabetes Mellitus

目的探讨糖化血红蛋白、糖化白蛋白与2型糖尿病早期肾损伤的关系。方法将40例2型糖尿病患者纳入糖尿病组,将40例早期糖尿病肾脏疾病(diabetic kidney disease,DKD)患者纳入早期DKD组,将40例健康体检者纳入对照组。比较三组一般资料、血浆糖化血红蛋白以及糖化白蛋白水平,采用Logistic回归分析2型糖尿病早期肾损伤的危险因素分析。结果单因素分析显示,年龄、体质量指数、三酰甘油、总胆固醇、血浆糖化血红蛋白以及血浆糖化白蛋白与2型糖尿病早期肾损伤有关(P <0.05);性别、嗜烟、嗜酒、收缩压以及舒张压与2型糖尿病早期肾损伤无关(P> 0.05)。Logistic回归分析显示,血浆糖化血红蛋白和血浆糖化白蛋白是2型糖尿病早期肾损伤的独立危险因素。结论血浆糖化血红蛋白升高和血浆糖化白蛋白升高与2型糖尿病早期肾损伤密切相关。

Objective To discuss therelationship between glycosylated hemoglobin,glycated albuminand and early kidney injury in patients with type 2 diabetes mellitus.Methods 40 patients with type 2 diabetes mellitus were enrolled in the diabetes group,40 patients with early(diabetic kidney disease)DKD were enrolled in the early DKD group,and 40 healthy people were enrolled in the control group.The general data,plasmalevels of glycosylated hemoglobin and glycated albumin were compared among the three groups.The risk factors of early renal injury in type 2 diabetes mellitus were analyzed by logistic regression.Results Univariate analysis revealed thatage,body mass index,triglyceride,total cholesterol,plasma glycosylated hemoglobin and plasmaglycosylated albumin are associated with early kidney injury in type 2 diabetes mellitus(P<0.05);Sex,smoking,alcohol,systolic blood pressure and diastolic blood pressure were not associated with early renal injury in type 2 diabetes mellitus(P>0.05).Logistic regression analysis showed that glycosylated hemoglobin;glycated albumin are risk factors forearly kidney injury in type 2 diabetes mellitus.Conclusion The elevation of plasma glycosylated hemoglobin and plasma glycosylated albumin is closely related to early kidney injury in type 2 diabetes mellitus.