预防性接种人乳头瘤病毒疫苗对妊娠结局的影响

Effects of preventive vaccination of human papillomavirus vaccines on pregnancy outcomes

高危型人乳头瘤病毒(HPV)持续感染可导致宫颈癌。目前,世界各国数以百万计育龄女性预防性接种HPV疫苗。最近10年对于孕期预防性接种HPV疫苗对自然流产、出生缺陷等不良妊娠结局影响的研究结果显示,接种HPV疫苗孕妇的自然流产率和重大出生缺陷发生率与未接种孕妇,或者预防性接种抗甲型肝炎病毒(HAV)疫苗孕妇比较,差异均无统计学意义(P>0.05)。笔者拟就预防性接种HPV疫苗现状,以及围生期或孕期预防性接种HPV疫苗对妊娠结局影响的最新研究进展进行阐述。

Persistent high-risk human papillomavirus(HPV)infection can lead to cervical cancer.Nowadays,millions of women in childbearing age around the world have been vaccinated with preventive HPV vaccines.Studies which mainly discussed the effects of HPV vaccines on adverse pregnancy outcomes including spontaneous miscarriage,major birth defects in the latest 10 years showed that the risks of spontaneous miscarriage and major birth defects of pregnant women with preventive vaccination of HPV vaccines during pregnancy were not significantly higher than those with preventive vaccination of hepatitis A vaccination(HAV)or without vaccination of HPV vaccines(P>0.05).In this article,we review the status of preventive vaccination of HPV vaccines,and summarize the latest research progresses of the effects of preventive vaccination of HPV vaccines on pregnancy outcomes during peri-conception or pregnancy.