槐杞黄颗粒对呼吸道合胞病毒毛细支气管炎患儿的治疗效果及免疫调节作用研究

Effect of Huaiqihuang granule on children with respiratory syncytial virus bronchiolitis and its immunomodulatory effect

目的探究槐杞黄颗粒对呼吸道合胞病毒(RSV)毛细支气管炎患儿的治疗效果及免疫调节作用。方法选择2016年7月至2017年6月大连市儿童医院呼吸科收治住院的RSV毛细支气管炎患儿90例为研究对象,随机分为对照组和观察组各45例。对照组采取常规治疗,观察组在对照组治疗基础上口服槐杞黄颗粒治疗,6个月为1个疗程。观察两组患儿治疗效果及免疫学指标(IgA、IgG、IgM、IgE及IL-17、IL-23)。结果观察组治疗总有效率为93.33%(42/45),显著高于对照组73.33%(33/45),差异有统计学意义(P<0.05)。观察组患儿临床症状消失、退热及住院时间均显著短于对照组,差异有统计学意义(P<0.05)。观察组治疗后IgA、IgG、IgM水平均显著高于对照组,IgE显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗后IL-17、IL-23水平均显著低于对照组,差异有统计学意义(P<0.05)。结论槐杞黄颗粒对RSV毛细支气管炎患儿的治疗效果显著,且可以增强免疫调节。

Objective To explore the effect of Huaiqihuang granule on children with respiratory syncytial virus(RSV)bronchiolitis and its immunomodulatory effect.Methods Ninety cases of RSV bronchiolitis were treated in our hospital from July 2016to June2017,and they were randomly divided into the control group and the observation group,45children in each group.The control group was treated with routine treatment,The observation group was treated with Huaiqihuang granule on the basis of the treatment for control group,6months as1course.The curative effect and immunological indexes(IgA,IgG,IgM,IgE and IL-17and IL-23)of the two groups were compared.Results The total effective rate of the observation group(93.33%,42/45)was significantly higher than that the control group(73.33%,33/45)(P<0.05).The time of clinical symptoms disappearing,antipyretic time and length of hospitalization in the observation group were significantly shorter than those of the control group(P<0.05).The level of IgA,IgG and IgM in the observation group was significantly higher than that of the control group,while the levels of IgE,IL-17and IL-23were significantly lower(P<0.05).Conclusion Huaiqihuang granule has significant effect on children with respiratory syncytial virus bronchiolitis.Immune regulation can be enhanced.