对比传统巴氏涂片法与液基细胞学法在宫颈癌筛查中的作用

Comparison of the role of traditional Pap smear and liquid-based cytology in screening of cervical cancer

目的:对比分析传统巴氏涂片法与液基细胞学法在宫颈癌临床筛查中的应用效果。方法:选择2016年4月至2017年4月在西安医学院第二附属医院接受宫颈癌临床筛查的女性2000例,按照就诊的顺序进行随机分组,每组100例,分别采集标本,接受传统巴氏涂片法筛查以及液基细胞学法筛查,并将检查结果与阴道镜活检检查结果进行比较。统计不同检测方法的制片满意度和阳性检出率,以及相应的筛查结果。结果:对不同检测方法下的制片情况进行评估,可得传统巴氏涂片法的制片满意度为78. 70%,显著低于液基细胞学法的99. 40%,差异具有统计学意义(P <0. 05)。统计不同检测方法的阳性率,存在组间统计学差异,传统巴氏涂片法的阳性检出率为1. 10%,显著低于液基细胞学法的7. 10%,差异具有统计学意义(P <0. 05)。对不同检测方法的检测结果与病理结果进行比较,并进行组间统计学比较,可得传统巴氏涂片法的不同病理学筛查结果符合率均显著低于液基细胞学法,差异具有统计学意义(P <0. 05)。结论:与传统巴氏涂片法进行比较,在宫颈癌筛查中应用液基细胞学法效果确切,可以提高制片满意度以及阳性检出率,并获得更好的病理学筛查效果,在宫颈癌的临床筛查中具有重要作用。

Objective:To compare and analyze the effect of traditional Pap smear and liquid-based cytology in the clinical screening of cervical cancer.Methods:2000 patients received clinical screening for cervical cancer in our hospital from April 2016 to April 2017 were randomly divided into two groups,100 cases in each group.Samples were collected for traditional Pap smear and liquidbased cytology screening,and the results were compared with vaginal mirror biopsy results.The production satisfaction and positive detection rate of different detection methods,as well as the corresponding screening results were statistically analyzed.Results:The satisfaction rate of the traditional Pap smear method was 78.70%,which was significantly lower than that of the liquid based cytology method(99.40%)with statistically significant difference(P<0.05).The positive rate of different detection methods was statistically different between groups.The positive rate of traditional Pap smear method was 1.10%,which was significantly lower than that of liquid based cytology(7.10%),with statistically significant difference(P<0.05).The coincidence rates of different pathological screening results of traditional Pap smear method were significantly lower than those of liquidbased cytology,with statistically significant difference(P<0.05).Conclusions:The application of liquid-based cytology in cervical cancer screening is effective compared with the traditional Pap smear method,which can improve the production satisfaction and positive detection rate with good pathological screening effect.