SCAG、CA125、β-HCG、CA199联合检测在宫颈癌的诊断中的应用价值

Application value of SCCAg,CA125,β-HCG and CA199 joint detection in the diagnosis of cervical cancer

目的:探索肿瘤标记物鳞癌抗原(SCCAg)、人绒毛膜促性腺激素(β-HCG)、CA125和CA199联合测定对宫颈癌早期诊断的意义。方法:选取2012年3月至2013年12月就诊于余姚市第四人民医院妇科并被诊断为宫颈癌的患者120名,诊断为良性宫颈肿瘤的病人120名以及健康人120名,对他们的鳞癌抗原(SCCAg)、人绒毛膜促性腺激素(β-HCG)、CA125和CA199进行测定,分析单一测定和全部指标测定所得数据的阳性率、敏感程度和正确程度。结果:宫颈癌组病人血液中的SCCAg、CA125、β-HCG、CA199浓度明显高于宫颈良肿瘤组和健康组;宫颈良性肿瘤组中患者血液中的的SCCAg、CA125、β-HCG、CA199的浓度与健康组相比较,P> 0. 05,差异无统计学意义。宫颈癌组各指标阳性检测率明显高于健康组,同时,低于联合检测阳性检测率;宫颈良性肿瘤组与健康组各指标阳性率比较,P> 0. 05,差异无统计学意义,两组的指标阳性检测率明显低于联合检测阳性检测率。联合指标测敏感性和准确性明显高于单一指标测定,P <0. 05,差异具有统计学意义。结论:在对宫颈癌的诊断中应用肿瘤标志物SCCAg、CA125、β-HCG、CA199联合检测所得结果更加准确,值得在临床中推广。

Objective:To investigate thesignificance of tumor marker of squamous cell carcinoma antigen(SCCAg),human chorionic gonadotropin(β-HCG),CA125 and CA199 joint detection for the early diagnosis of cervical cancer.Methods:120 patients with cervical cancer and120 patients with benign cervical tumor diagnosed in our hospital from March 2012 to December 2013 and 120 healthy people were selected.The SCCAg,CA125,β-HCG andCA199 of the three groups were detected and the positive rate,sensitive and accurate degrees were compared between single detection and joint detection.Results:The serum SCCAg,CA125β-HCG and CA199 concentrations in the cervical cancer group were significantly higher than those in the benign cervical tumorgroup and healthy group while difference betweenthe benign cervical tumor group and healthy groupwas not statistically significant(P>0.05).The positive detection rate of each index in the cervical cancer group was significantly higher than that in the healthy group,but lower than that of joint detection,while difference in the positive detection rate between the benign cervical tumor group and healthy group was not statistically significant(P>0.05).The positive rateof single index detection was significantly lower than that of joint indexes detection,and the sensitive and accurate degreesof single index detection was significantly lower than those of joint indexes detection,with statistically significant difference(P<0.05).Conclusions:Joint application of cervical cancer tumor markers SCCAg,CA125,β-HCG and CA199 can improve the accurate rate of the diagnosis of cervical cancer,which is worthy of promotion in clinical.