曲普瑞林联合达那唑预防子宫内膜异位症术后复发的效果分析

Prevention reoccurrence analysis of Triptorelin combined with Danazol on endometriosis (EM) after operation

目的:探讨曲普瑞林联合达那唑预防子宫内膜异位症术后复发的效果。方法:选取80例行腹腔镜手术治疗的子宫内膜异位症患者,将其随机分为观察组与对照组,每组40例患者。观察组患者术后予以曲普瑞林和达那唑治疗预防复发,对照组患者术后予以达那唑治疗预防复发。比较两组患者的治疗效果和不良反应发生情况。结果:两组患者治疗前FSH、E2水平和痛经评分比较,其差异均无统计学意义(均P> 0. 05),两组患者治疗后FSH、E2水平和痛经评分均比治疗前下降(P <0. 05或P <0. 01),观察组患者下降幅度明显大于对照组患者(P <0. 05);观察组患者治疗后临床总有效率明显优于对照组患者(P <0. 05);两组患者治疗后不良反应发生率比较,差异无统计学意义(P> 0. 05)。结论:采用曲普瑞林联合达那唑预防子宫内膜异位症术后复发效果显著,能够明显改善患者临床症状、减少不良反应,是一种安全有效的治疗方案。

Objective:To discuss the prevention reoccurrence analysis of Triptorelin combined with Danazol on endometriosis(EM)after the operation.Methods:80 cases of patients with EM,who were given the laparoscopic surgery in Taizhou Maternal and Child Health Care Hospital,were selected and divided into observation group and control group at random.The patients in observation group were given Triptorelin combined with Danazol for prevention reoccurrence,while the patients in control group were only given Danazolfor prevention reoccurrence.The curative effect and occurrence of untoward effect of patients in two groups were observed.Results:After comparing the FSH and E2 levels and dysmenorrhea scores of patients in two groups before the medical treatment,no statistical differences were appeared(all P>0.05),while the FSH,and E2 levels and dysmenorrhea scores of patients in two groups after the medical treatment were greatly decreased than before(P<0.05 or P<0.01).The improvement rates of patients in observation group were much higher than those in control group(P<0.05),and the curative effect of patients in observation group was much higher than that in control group after the medical treatment(all P<0.05).After comparing the occurrence rates of untoward effect of patients in two groups after the medical treatment,no statistical differences appeared(P>0.05).Conclusions:The triptorelin combined with Danazol has significant prevention reoccurrence on patients with EM after the medical treatment,and can obviously improve clinical symptom with little untoward effect,which can be a safe and effective method of treatment.