硝酸咪康唑与制霉素治疗妊娠合并念珠菌性阴道炎的疗效观察及对患者性生活质量的影响

Efficacy of miconazole nitrate and mycin in the treatment of pregnancy with Candidal vaginitis and its effect on the quality of sexual life of patients

目的:探讨硝酸咪康唑与制霉素治疗妊娠合并念珠菌性阴道炎的疗效及对患者性生活质量的影响。方法:选取2015年10月至2016年12月西安市中心医院收治的妊娠合并念珠菌性阴道炎患者120例为研究对象,依据治疗药物的不同将其随机分为对照组和研究组,每组60例患者。研究组患者采用硝酸咪康唑治疗,对照组采用制霉素治疗,比较两组患者的治疗效果及对性生活质量的影响。结果:采用不同的药物治疗后,研究组患者的治疗有效率为96. 7%,对照组患者的治疗有效率为95. 0%,两者差异无统计学意义(P> 0. 05);治疗后,研究组患者不良反应发生率为8. 3%,对照组患者不良反应发生率为16. 7%,研究组患者不良反应发生率明显低于对照组患者(P <0. 05);两组患者分娩后均出现了携带真菌的新生儿,新生儿真菌携带率差异无统计学意义(P> 0. 05);治疗前两组患者的性生活质量无明显区别(P> 0. 05),治疗后研究组患者的性生活质量明显优于对照组患者(P <0. 05)。结论:硝酸咪康唑和制霉素对于妊娠合并念珠菌性阴道炎患者都有良好的治疗效果,硝酸咪康唑可以有效降低治疗后不良反应的发生率,还可以提高患者的性生活质量,更加安全有效,值得推广和应用。

Objective:To investigate the effect of miconazole nitrate and mycin on the treatment of pregnancy with Candidal vaginitis and its effect on the quality of sexual life of patients.Methods:120 pregnant women with Candidal vaginitis admitted into Xi′an Central Hospital from October 2015 to December 2016 were randomly divided into control group and study group according to the different treatment received.The control group was treated with mycin and the study group was treated with miconazole nitrate.The treatment efficiency and its effect on the quality of sexual life was compared between the two groups.Results:The treatment effective rate was 96.7%and 95.0%in the study group and control group respectively,without statistically significant difference(P>0.05).The incidence of adverse reactions was 8.3%and 16.7%in the study group and control group respectively,with statistically significant difference(P<0.05).There were newborns with fungus in the two groups without statistically significant difference between the two groups(P>0.05).There was no statistically significant difference in the quality of sexual life between the two groups before treatment(P>0.05)while the quality of sexual life of patients in the study group was significantly better than that of the control group(P<0.05).Conclusions:Miconazole nitrate and mycin is of good therapeutic effect for patients with Candidal vaginitis,but miconazole nitrate can effectively reduce the incidence of adverse reactions after treatment and improve the quality of sexual life of patients,which is safer and more effective,worthy of promotion and application.