升陷汤治疗慢性心力衰竭心肺气虚证的临床观察

Clinical Observation on Shengxian Decoction in Treating Chronic Heart Failure with Cardiopulmonary Qi Deficiency Syndrome

目的观察升陷汤加减治疗心肺气虚型慢性心力衰竭患者的临床疗效。方法将60例中医辨证为心肺气虚的慢性心力衰竭患者随机分为治疗组和对照组,2组均给予西医综合治疗,治疗组在西医综合治疗基础上口服中药,以升陷汤为主方加减,治疗时间4周。观察2组治疗前后中医症状积分、血清脑钠肽(BNP)、左心室射血分数(LVEF)及用药安全性指标。结果治疗后2组中医症状疗效、BNP和LVEF均较治疗前明显改善(P<0.05),且治疗组改善程度优于对照组(P<0.01)。结论升陷汤加减可明显改善慢性心力衰竭心肺气虚证患者临床症状和心功能情况,未发现明显毒副作用。

Objective To evaluate the clinical effect of the Shengxian decoction in treating chronic heart failure with cardiopulmonary qi deficiency syndrome.Methods 60 chronic heart failure patients with cardiopulmonary qi deficiency syndrome were randomly divided into the treatment group and the control group.Both two groups received the same western medicine treatment,while the treatment group was also given the Shengxian decoction.The total treatment for both groups lasted 4 weeks.The scores of Traditional Chinese Medicine symptoms,serum brain natriuretic peptide(BNP),left ventricular ejection fraction(LVEF)and treatment of drug safety index.Results Compared with those before treatment in both groups,TCM symptom scores,BNP and LVEF after treatment were significantly improved,and the improvement in the treatment group was markedly superior to that in the control group.Conclusion The Shengxian decoction can significantly improved the clinical symptoms and heart function in chronic heart failure patients with cardiopulmonary qi deficiency syndrome.