活血行痹汤联合硫辛酸治疗糖尿病周围神经病变的临床研究

Clinical Study on Huoxue Xingbi Decoction Combined with Lipoic Acid in the Treatment of Diabetic Peripheral Neuropathy

目的观察活血行痹汤联合硫辛酸治疗糖尿病周围神经病变的临床疗效。方法将40例糖尿病周围神经病变患者随机分为治疗组和对照组,每组20例。2组均进行降糖治疗,对照组在此基础上使用α-硫辛酸300 mg/d,静脉滴注,实验组采用α-硫辛酸300 mg/d静脉滴注+中药口服,2次/日。2组疗程均为1个月,所有病例在治疗前及治疗后,逐项询问观察自觉症状轻重,并进行温度觉、振动觉、腱反射、膝反射检查,检测下肢正中神经及腓总神经传导速度,测空腹血糖及糖化血红蛋白。结果与对照组相比,治疗组在自觉症状、温度觉、振动觉、腱反射、膝反射检查等方面明显改善,且差异具有统计学意义(P<0.05)。治疗组下肢正中神经及腓总神经传导速度明显提高,与对照组相比有显著性差异(P<0.05)。2组空腹血糖及糖化血红蛋白差异不显著(P>0.05)。结论相较于单纯应用α-硫辛酸,联合活血行痹汤治疗糖尿病周围神经病,能够更好地改善患者的临床症状及生活质量。

Objective To observe the clinical curative effect of the Huoxue Xingbi decoction combined with theα-lipoic acid in the treatment of diabetic peripheral neuropathy.Methods 40 cases of diabetic peripheral neuropathy patients were randomly divided into the treatment group and the control group,with 20 cases in each group.Both groups were given hypoglycemic therapy.On this basis,the control group was drippedα-lipoic acid 300 mg/d.The treatment group was drippedα-lipoic acid 300 mg/d,combining with traditional Chinese medicine.Before and after a month,self-conscious symptoms would be observed,and the temperature sense,vibration sense,tendon reflex,knee reflex,nerve conduction velocity of median nerve and sural of lower limbs,fasting blood glucose,and glycosylated hemoglobin.Results Compared with the control group,the treatment group had a better effect in improving self-conscious symptoms,temperature sense,vibration sense,tendon reflex,knee reflex examination etc,and the difference was statistically significant(P<0.05).In the treatment group,the conduction velocity of the median nerve and sural total nerve of lower extremities increased more significantly,comparing with the control group.The difference was statistically significant(P<0.05).The fasting blood sugar and glycated hemoglobin was similar between the two groups,with no significant(P>0.05).Conclusion Compared with a simplecα-lipoic acid,combining with Huoxue Xingbi decoction could achieve better therapeutic effects in improving the clinical symptoms and quality of life of the diabetic peripheral neuropathy patients.