肿瘤标志物及血管新生因子与结直肠癌患者临床分期及肿瘤转移相关

Tumor markers and angiogenic factors are related to clinical stages and metastasis in colorectal cancer patients

目的探讨肿瘤标志物及血管新生因子与结直肠癌临床分期及肿瘤转移的关系。方法用电化学发光法及酶联免疫吸附法检测结直肠癌患者及同期来医院健康体检者各100例静脉血肿瘤标志物与血管新生因子水平,并分析其与肿瘤不同TNM分期及肿瘤转移之间的关系。结果癌患者CEA、CA19-9、Ang-2、VEGF及IGF-1水平均显著高于对照组(P<0. 05);不同TNM分期间CEA、CA19-9、Ang-2、VEGF及IGF-1水平有明显差异(P<0. 05),随着肿瘤进展,CA19-9、Ang-2及IGF-1水平均显著升高(P<0. 05),Ⅳ期CEA及VEGF水平较Ⅰ、Ⅱ与Ⅲ期显著升高(P<0. 05);肿瘤转移组患者的CEA、CA19-9、Ang-2、VEGF及IGF-1水平均显著高于无转移(P<0. 05)。结论结直肠癌患者存在肿瘤标志物及血管新生因子水平异常升高,其指标水平检测对评估肿瘤分期及转移预测具有重要临床价值。

Objective To investigate the relationship between tumor markers and angiogenesis factors and clinical staging and metastasis of colorectal cancer. Methods The level of tumor markers and angiogenic factors in 100 colorectal cancer patients and 100 healthy people in the same period were detected by electrochemiluminescence and enzyme-linked immunosorbent assay,the relationship between the levels of tumor markers and angiogenic factors with TNM staging and tumor metastasis of different tumors was analyzed. Results The level of CEA,CA19-9,Ang-2,VEGF and IGF-1 in the cancer patients was significantly higher than those in the control group (P<0.05). Single factor variance results showed that there was a significant difference in CEA,CA19-9,Ang-2,VEGF and IGF-1 levels between different TNM scores (P<0.05). With the progression of tumor,CA19-9,Ang-2 and IGF-1 levels increased significantly (P<0.05),compared with the stage Ⅰ,Ⅱ and Ⅲ,the levels of CEA and VEGF in the stage IV were significantly increased (P<0.05). The level of CEA,CA19-9,Ang-2,VEGF and IGF-1 in tumor metastasis group was significantly higher than those in non metastasis group,and the difference was statisti- cally significant (P<0.05). Conclusions The level of tumor marker and angiogenesis factors in the colorectal cancer patients is increased,the detection of its index level has an important value in evaluating tumor staging and metastasis prediction.