血脑屏障损伤诱发神经病变的评估方法及机制研究进展

Research progress in assessment methods and mechanisms of neural disease induced by blood-brain barrier injury

血脑屏障(BBB)是人体的生理屏障结构,发挥维持中枢神经系统内环境稳定的重要作用。中枢神经系统疾病如颅脑创伤、颅内肿瘤和神经退行性病变等均可以引起血脑屏障的损害。此外,血脑屏障损伤可以诱发中枢神经系统病变。目前,缺乏简明精确的血脑屏障评估手段成为中枢神经病变临床实践和研究的一个限制性因素。因此,血脑屏障评估技术及其完整性对中枢神经系统病变的意义十分重要。

The blood-brain barrier (BBB)is a significant physiological barrier separately the central neural system with peripheral blood circulation.It plays an essential role in maintaining the brain homeostasis.Many neurological conditions are accompanied with blood-brain barrier disruption(e.g.traumatic brain injury,intracranial tumor,chronic neurodegenerative disorders).Recently many experiments have suggested that the blood-brain barrier disruption may be a cause rather than just a result from brain damage which suggested that the BBB is an important therapeutic target.However,the current lack of concise and accurate blood-brain barrier assessment has become a limiting factor in the clinical practice and research of central neuropathy.