CYP2C19基因多态性与老年人脑梗死的相关性

Correlation between CYP2C19 Gene Polymorphism and Elderly Cerebral Infarction

目的探讨细胞色素P450 2C19 (CYP2C19)基因多态性与老年人脑梗死的相关性。方法采用基因芯片技术对浙江医院72例新发的老年急性脑梗死患者(病例组)和77例同期住院体检者(对照组)的CYP2C19基因rs4244285、rs4986893两个单核苷酸多态位点进行基因分型,比较两组临床资料、CYP2C19基因多态性,Logistic回归分析该基因多态性与老年脑梗死的相关性。结果脑梗死组及对照组rs4244285 GG型(45. 83%比63. 64%,χ~2=4. 766,P=0. 029)、rs4244285 A等位基因(34. 03%比22. 73%,χ~2=4. 695,P=0. 030)分布差异有统计学意义。而rs4986893不同基因型、等位基因及rs4244285 GA型、AA型分布差异均无统计学意义(P均> 0. 05)。Logistic回归分析调整性别、年龄、体质量指数、吸烟、总胆固醇等传统脑血管危险因素后,rs4244285位点携带A等位基因患脑梗死风险增加(加性模型AA比GG OR=2. 564,95%CI=1. 181～5. 566,P=0. 017;显性模型AA/AG比GG OR=2. 763,95%CI=1. 343～5. 685,P=0. 006)。结论 CYP2C19基因多态性与老年人脑梗死患病风险增加有关,但仍需大样本人群进一步研究。

Objective To investigate the correlation between CYP2C19 gene polymorphism and elderly cerebral infarction.Methods Two polymorphisms including rs4244285 and rs4986893 of the CYP2C19 gene were detected by gene chip technology in 72 elderly patients with acute cerebral infarction(stroke group)and 77 otherwise healthy controls.The clinical data and the polymorphism distribution of CYP2C19 were compared,and the potential association between genetic polymorphism and cerebral infarction was analyzed by Logistic regression.Results The frequencies of rs4244285 GG(45.83%vs.63.64%,χ^2=4.766,P=0.029)and rs4244285 A allele(34.03%vs.22.73%,χ^2=4.695,P=0.030)were significantly higher in stroke group than in control group.There were no significant differences in the distribution of the alleles of rs4986893 or the rs4244285 GA and AA between these two groups(all P>0.05).After the conventional cerebrovascular risk factors including gender,age,body mass index,smoking,and total cholesterol were adjusted,Logistic regression analysis showed that rs4244285 A allele significantly increased the stroke risk[the additive model AA vs.GG:OR=2.564,95%CI=1.181-5.566,P=0.017;the dominant model AA/AG vs.GG:OR=2.763,95%CI=1.343-5.685,P=0.006].Conclusion CYP2C19 genetic polymorphism may be associated with the increased risk of cerebral infarction in the elderly,although future well-designed studies with larger sample sizes are warranted.