细胞焦亡在眼部疾病中的研究进展

Research progress of pyroptosis in ocular diseases

细胞焦亡与细胞凋亡、细胞坏死及自噬不同,是一种程序性促炎性细胞死亡方式。其主要信号通路包括依赖caspase-1的经典焦亡途径和依赖caspase-4/5、caspase-11的非经典焦亡途径。已有大量研究表明,细胞焦亡与感染性疾病、动脉粥样硬化性疾病、代谢性疾病及重要脏器非细菌性炎性疾病相关。近几年细胞焦亡在眼部疾病中也有部分研究,包括老年性黄斑变性、角膜炎、白内障等疾病。本文主要综述细胞焦亡的主要机制及其在眼部疾病中的研究进展。

Pyroptosis is a programmed pro-inflammatory cell death mode which different from apoptosis,necrosis and autophagy. The main signaling pathways include classic caspase-1-dependent pyroptosis and non-classical caspase-4/5-dependent and caspase-11 dependent pyroptosis. A large number of studies have shown that pyroptosis is associated with infectious diseases,atherosclerotic diseases,metabolic diseases and important nonbacterial inflammatory diseases of organs. In recent years,pyroptosis has been studied in some eye disease,including age-related macular degeneration,keratitis,cataract and other diseases. The main mechanism of pyroptosis and its progress in ocular diseases will be reviewed in this paper.