早期复发性流产患者血浆维生素D水平及其与D-二聚体的相关性研究

The Correlation Between Plasma Vitamin D and D-dimer in Women with Recurrent Spontaneous Abortion(RSA)

目的:检测复发性流产(RSA)患者血清维生素D (维生素D)水平并探讨其与D-二聚体(D-DI)表达的相关性。方法:回顾性分析179例(包括对照组49例、RSA组65例及不孕组65例)患者血浆总维生素D水平和D-DI水平。结果:RSA组和不孕组患者血浆维生素D水平低于对照组,差异有统计学意义(P <0. 05),但RSA组和不孕组两组患者间维生素D水平无显著性差异。RSA组血浆D-DI水平显著高于不孕组及对照组(P <0. 05);RSA组维生素D水平与D-DI呈负相关,但无统计学意义。结论:RSA患者及不孕患者中维生素D不足的比例较高;RSA组维生素D水平不足及其与之相关的血浆D-DI增高倾向,可能参与早期复发性流产的发生。

Objective To detect the concentration of plasma vitamin D and explore the correlation between plasma vitamin D and D-dimer in women with spontaneous abortion(RSA).Method The plasma levels of vitamin D and D-dimer in 179 women(including 49 controls,65 RSA women and 65 infertile women)were retrospectively analyzed.Result Vitamin D levels in RSA and infertile group were significantly lower than that in the control group(P<0.05),while there was no difference between the RSA and infertile group.The D-dimer levels in RSA group was significantly higher than those in infertile group or the control group.The plasma vitamin D levels were negatively correlated with D-dimer in RSA group,while without statistic significance.Conclusion There was a high proportion of women with vitamin D insufficiency in RSA and infertile group.The insufficiency of vitamin D and the increase of D-Dimer may play a role in the pathogenesis of RSA.