急性脑梗死患者血清PAF、P选择素与颈动脉粥样硬化斑块稳定性的关系

Relationship between serum PAF and P selectin and carotid atherosclerotic plaque stability in patients with acute cerebral infarction

目的探讨急性脑梗死患者血清血小板活化因子(PAF)、P选择素与颈动脉粥样硬化斑块稳定性的关系。方法选取2018年2月-2018年6月在佳木斯大学附属第一医院神经内科住院的前循环急性脑梗死患者95例为实验组,根据颈动脉彩色多普勒超声结果将其分为无斑块组(25例)、稳定性斑块组(30例)、不稳定性斑块组(40例);另取颈动脉超声提示内膜中膜厚度(IMT)≤1.0 mm的健康体检者35例为对照组。ELISA法对所有受试者进行血清PAF、P选择素浓度的测定,进行统计学分析。结果实验组各组血清PAF、P选择素水平均明显高于对照组(P <0. 05);且血清PAF和P选择素在不稳定性斑块组的表达明显高于稳定性斑块组(P <0. 01)。结论血清PAF、P选择素水平与颈动脉斑块的形成和稳定性有关。血清PAF、P选择素可能是颈动脉斑块形成和稳定性的预测因子。

Objective To discuss the relationship between serum platelet activation factor(PAF)and P selectin in patients with acute cerebral infarction and the stability of carotid atherosclerotic plaques.Methods From February to June 2018,95 patients in the department of neurology of the first affiliated hospital of Jiamusi University with acute precirculatory cerebral infarction were included in the experimental group.They were divided into non-plaque group(25 cases),stable plaque group(30 cases),and unstable plaque group(40 cases),which was based on the results of carotid color Doppler ultrasound.The control group was 35 healthy persons who came to the hospital for physical examination.Carotid ultrasonography indicated that the thickness of carotid intima-media(IMT)was no more than 1.0 mm.Serum PAF and P selectin concentrations were measured by ELISA.Results In the experimental group,serum PAF,was significantly increased and pselectin was decreased in the control group(P<0.05)and serum PAF and P selectin levels increased in unstable plaque group and decreased in stable plaque group(P<0.01).Conclusion The level of serum PAF and P selectin is related to the formation and instability of carotid plaques.Serum PAF and P selectin may be the predictors of carotid plaque formation and instability.