增加盐酸氨溴索治疗老年慢性阻塞性肺疾病的疗效观察

Effects of ambroxol hydrochloride on oxygenation function and inflammatory factors in elderly patients with chronic obstructive pulmonary disease

目的分析盐酸氨溴索辅助治疗对老年慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)氧合功能和炎性因子的影响。方法分析2015年3月—2016年12月于湖北医药学院附属人民医院治疗的老年COPD患者144例,随机分为2组,每组72例。对照组采用常规疗法进行治疗,研究组在此基础上采用盐酸氨溴索进行治疗。分别于治疗前后测定所有患者炎性因子及氧合功能指标水平,并统计2组治疗不良反应情况。结果测定并计算2组氧合功能指标发现,治疗1个疗程后,2组动脉氧分压(PaO2)、氧合指数(OI)水平有所降低,吸入氧气分率(FiO2)、肺泡-动脉氧分压差[P(A-a)O2]、呼吸指数(RI)水平有所升高,2组差异具有统计学意义(P<0.05);2个疗程治疗后,与治疗1个疗程比较,2组PaO2、OI水平有所上升,FiO2、P(A-a)O2、RI水平有所降低,2组数据差异具有统计学意义(P<0.05)。监测2组炎性因子水平发现,治疗后与治疗前各项指标水平均有所降低,最终研究组各项炎性因子水平明显低于对照组(P<0.05)。经统计,研究组治疗期间不良反应共13例(18.06%),对照组治疗期间不良反应16例(22.22%),2组差异无统计学意义(P>0.05)。结论盐酸氨溴索用于老年COPD的治疗具有一定的优越性,能有效降低患者炎性因子水平,显著改善其氧合功能,并不会增加不良反应发生,在临床治疗中值得推广应用。

Objective To analyze the effects of ambroxol hydrochloride on oxygenation function and inflammatory factors in elderly patients with chronic obstructive pulmonary disease.Methods A total of 144 patients with chronic obstructive pulmonary disease(COPD)treated in People's Hospital Affiliated to Hubei Medical College from March 2015 to December 2016.144 patients with COPD were equally divided into the study group and control group.Patients in the control group received conventional therapies,while patients in the study group were treated with ambroxol hydrochloride combined with conventional therapies.Levels of inflammatory factors and oxygenation indexes of all the patients were measured before and after treatment,and adverse reactions were compared between the two groups.Results After one course of treatment,levels of PaO2 and OI of the two groups decreased,while levels of FiO2,P(A-a)O2 and RI increased.The difference between the two groups was of statistical significance(P<0.05).After two courses of treatment,levels of PaO2 and OI increased in both groups,while levels of FiO2,P(A-a)O2 and RI decreased.The difference between the two groups was also of statistical significance(P<0.05).The levels of inflammatory factors of the two groups were decreased after treatment,especially in the study group.The difference was statistically significant(P<0.05).According to statistics,there were 13 cases of adverse reactions in the study group(18.06%),compared with 16 cases(22.22%)in the control group.There was no significant difference between the two groups(P>0.05).Conclusion Ambroxol hydrochloride in the treatment of elderly patients with chronic obstructive pulmonary disease has some advantages.It can effectively reduce the level of inflammatory factors,and improve the oxygenation function of patients significantly.Also,this therapy causes no increase in the incidence of adverse reactions.It is worthy of popularization and application.