慢性牙周炎伴肥胖患者牙周基础治疗后脂联素及其相关分子水平改变的临床研究

Clinical study of adiponectin and its related molecular level after periodontal treatment in patients with chronic periodontitis and obesity

目的探讨慢性牙周炎肥胖患者牙周基础治疗后龈沟液中脂联素分子水平的改变。方法选择2015年12月—2017年12月期间收治的40例牙周健康患者(healthypatients,HP组)、40例慢性牙周炎患者(chronicperiodontitis,CP组)及40例慢性牙周炎伴肥胖患者(chronicperiodontitiswithobesity,CP+OB组);所有患者于第1次就诊时予以牙周探诊记录探诊深度,收集龈沟液并行脂联素分子水平检测;HP组予以龈上洁治治疗,CP组及CP+OB组予以龈上洁治及牙周基础治疗;治疗结束1年后复诊,再次予以牙周探诊记录探诊深度,收集龈沟液并行脂联素分子水平检测;进行数据统计分析。结果治疗前CP组及CP+OB组中脂联素分子水平均低于HP组(P<0.05);治疗后CP组中脂联素分子水平上升,与HP组比较差异无统计学意义(P>0.05),CP+OB组中脂联素分子水平上升,低于HP组及CP组(P<0.05)。结论慢性牙周炎伴肥胖患者经过牙周基础治疗后脂联素分子水平出现回升,但是无法恢复至健康水平。

Objective To investigate the changes of adiponectin levels in gingival crevicular fluid after periodontal treatment in obese patients with chronic periodontitis.Methods Forty cases of periodontally healthy patients(group HP),40 cases of chronic periodontitis(group CP)and 40 cases of chronic periodontitis with obesity(group CP+OB)were selected between December 2015 and December 2017.All the patients had their periodontal detection depth detected during the first visit,the gingival crevicular fluid was collected and the level of adiponectin was determined.Group HP was treated with gingival cleaning,while group CP and group CP+OB were treated with gingival cleaning plus periodontal treatment.One year after treatment,these patients were reexamined.The depth of detection was recorded with periodontal detection,and gingival crevicular fluid was collected and the level of adiponectin was detected.Results Before treatment,the levels of adiponectin molecules in group CP and group CP+OB were lower than that in group HP(P<0.05).After treatment,the level of adiponectin molecules increased in group CP,but was not significantly different from that of group HP(P>0.05).The level of adiponectin molecules increased in group CP+OB,but was lower than that in group HP and group CP(P<0.05).Conclusion Adiponectin levels in patients with chronic periodontitis and obesity can be recovered after periodontal treatment,but cannot be restored to a healthy level.