可溶性血管内皮生长因子受体1对重症急性胰腺炎的早期预测价值

The early prediction value of soluble vascular endothelial growth factor receptor 1 in severe acute pancreatitis

目的探讨可溶性血管内皮生长因子受体1(sFLT-1)在对重症急性胰腺炎(SAP)的早期预测价值。方法选取2015年8月至2017年12月期间在本院明确为急性胰腺炎(AP)的患者65例,分为轻型急性胰腺炎(MAP)组和SAP组,选取同期健康体检人群30例作为健康对照组。对AP患者进行APACHEⅡ评分,用ELISA法检测血浆sFLT-1、C反应蛋白(CRP)水平,比较各组间指标的差异,分析sFLT-1对SAP的早期预测价值。结果 (1)SAP组患者sFLT-1、CRP水平明显高于MAP组和健康对照组,两组比较差异有统计学意义(P<0.05);(2)sFLT-1、CRP、APACHEⅡ评分诊断SAP的的ROC曲线下面积分别为0.945、0.775、0.916,灵敏度分别为0.885、0.692、0.855,特异度分别为0.923、0.769、0.897,对诊断SAP的最佳界值分别为225 ng/L、23 mg/L、8分;(3)sFLT-1与CRP、APACHEⅡ评分呈正相关。结论 SAP患者血清sFLT-1水平明显升高,sFLT-1水平与病情程度呈正相关,sFLT-1可用于SAP早期预测。

Objective To investigate the early predictive value of soluble vascular endothelial growth factor receptor 1(sflt-1)in severe acute pancreatitis(SAP).Methods Selected 65 patients with acute pancreatitis(AP)in our hospital from August 2015 to December 2017,which were divided into the mild acute pancreatitis(MAP)group and the SAP group.Selected 30 healthy people at the same time as control group.The AP patients were given an APACHEⅡscore.Detected the serum levels of sflt-1 and CRP by ELISA.Compared the difference of the indexes of each group,and analyze the early prediction value of sflt-1 to SAP.Results①The sflt-1 and CRP levels of SAP group were significantly higher than MAP group and control group,the difference was statistically significant(P<0.05).②The area under the ROC curve of SFLT-1,CRP,APACHEⅡscore was 0.945,0.775 and 0.916,respectively.The sensitivity was 0.885,0.692,0.855,and the specificity was 0.923,0.769,0.897,respectively.The optimal thresholds for diagnosis of SAP were 225 ng/L,23 mg/L and 8 points respectively.③The level of Sflt-1 was positively correlated with CRP and APACHEⅡscores.Conclusion The serum level of sflt-1 in SAP patients was significantly increased.The level of sflt-1 was positively correlated with the severity of SAP.Sflt-1 could be used for early prediction of SAP.